2-巯基-N-甲基苯甲酰胺合成路线 （共 23 条）
反应条件
1.1: triethylamine
2.1: 3-chloro-benzenecarboperoxoic acid / chloroform / 0.83 h / 0 °C
3.1: n-butyllithium / tetrahydrofuran; N,N,N',N',N'',N''-hexamethylphosphoric triamide; hexane / 0.17 h / -70 °C / Inert atmosphere
3.2: -78 °C / Inert atmosphere
4.1: 2,4,6-trimethyl-pyridine; trifluoroacetic anhydride / dichloromethane / 0 - 20 °C / Inert atmosphere
View Scheme
参考文献
Pinna, Giovanni; Bellucci, Maria Cristina; Malpezzi, Luciana; Pisani, Laura; Superchi, Stefano; Volonterio, Alessandro; Zanda, Matteo
Tetrahedron, 2011 , vol. 67, # 29 p. 5268 - 5281
反应条件
cesium hydroxide; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene; tris-(dibenzylideneacetone)dipalladium(0) in N,N-dimethyl-formamide
T=70°C; 0.5 h;
参考文献
Agouron Pharmaceuticals, Inc.
Patent: US2006/94881 A1, 2006 ;
Location in patent: Page/Page column 21; 22 ;
US 20060094881 A1
反应条件
potassium carbonate in N,N-dimethyl-formamide
参考文献
Tarkiainen, Jari; Vercouillie, Johnny; Emond, Patrick; Sandell, Johan; Hiltunen, Jukka; Frangin, Yves; Guilloteau, Denis; Halldin, Christer
Journal of Labelled Compounds and Radiopharmaceuticals, 2001 , vol. 44, # 14 p. 1013 - 1024
