(1R,4R)-2-薄荷油-1,8-二醇合成路线 （共 7 条）
反应条件
water; acetic acid in n-heptane T=0 - 5°C; Product distribution / selectivity;
参考文献
CEDARBURG PHARMACEUTICALS, INC.
Patent: WO2005/100333 A1, 2005 ;
Location in patent: Page/Page column 17-18 ;
反应条件
water; acetic acid in n-heptane T=0 - 10°C; 2 h; Product distribution / selectivity;
参考文献
CEDARBURG PHARMACEUTICALS, INC.
Patent: WO2005/100333 A1, 2005 ;
Location in patent: Page/Page column title page; 3/7; 16 ;
反应条件
1: 2 percent Spectr. / oxygen; zeolite NaY / Irradiation; photooxygenation 2: 100 percent / LiAlH4 / diethyl ether View Scheme
参考文献
Stratakis, Manolis; Sofikiti, Nikoletta; Baskakis, Constantinos; Raptis, Christos
Tetrahedron Letters, 2004 , vol. 45, # 28 p. 5433 - 5436
反应条件
(i) AcOOH, NaOAc, CH2Cl2, (ii) KOH, MeOH; Multistep reaction;
参考文献
Arbuzov,B.A. et al.
Doklady Chemistry, 1972 , vol. 204, p. 501 - 503
Dokl. Akad. Nauk SSSR Ser. Khim., 1972 , vol. 204, # 5 p. 1115 - 1117
反应条件
boron trifluoride diethyl etherate; magnesium sulfate in dichloromethane T=5 - 12°C;
参考文献
WO2009/99868 A1, ;
Page/Page column 26-27 ;
反应条件
1: With magnesium sulfate in dichloromethane T=20°C; 0.166667 h; 2: With boron trifluoride diethyl etherate in dichloromethane T=3 - 12°C;
参考文献
MALLINCKRODT INC.
Patent: WO2009/99868 A1, 2009 ;
Location in patent: Page/Page column 28 ;
反应条件
hydrogen; palladium on activated charcoal in ethyl acetate
参考文献
Ohloff,G.; Giersch,W.
Helvetica Chimica Acta, 1968 , vol. 51, p. 1328 - 1342
