1-(2’-O,4-C-甲桥-BETA-D-呋喃核糖基)尿苷合成路线 （共 32 条）
反应条件
hydrogen; palladium on activated charcoal in methanol T=20°C; 15 h;
参考文献
Bioorganic and medicinal chemistry, , vol. 9, # 4 p. 1001 - 1011
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran T=20°C; 2 h;
参考文献
US2013/41011 A1, ;
Paragraph 0264; 0270 ;
反应条件
hydrogen; palladium dihydroxide in ethanol 4 h;
参考文献
Tetrahedron, , vol. 54, # 14 p. 3607 - 3630
反应条件
methanol; sodium methylate T=20°C; debenzoylation; 0.166667 h;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 10, # 20 p. 2287 - 2289
反应条件
1: 80 percent / ZnCl2 / 5 h / 20 °C 2: 75 percent / NaBH3CN; TiCl4 / acetonitrile / 15 h / 0 °C 3: 61 percent / NaN(SiMe3)2 / tetrahydrofuran / 3 h / 20 °C 4: 100 percent / H2 / Pd/C / methanol / 15 h / 20 °C View Scheme
参考文献
Bioorganic and medicinal chemistry, , vol. 9, # 4 p. 1001 - 1011
反应条件
1: 61 percent / NaN(SiMe3)2 / tetrahydrofuran / 3 h / 20 °C 2: 100 percent / H2 / Pd/C / methanol / 15 h / 20 °C View Scheme
参考文献
Bioorganic and medicinal chemistry, , vol. 9, # 4 p. 1001 - 1011
反应条件
1: 75 percent / NaBH3CN; TiCl4 / acetonitrile / 15 h / 0 °C 2: 61 percent / NaN(SiMe3)2 / tetrahydrofuran / 3 h / 20 °C 3: 100 percent / H2 / Pd/C / methanol / 15 h / 20 °C View Scheme
参考文献
Bioorganic and medicinal chemistry, , vol. 9, # 4 p. 1001 - 1011
反应条件
1: 94 percent / aq. TFA / 0.17 h / 20 °C 2: 80 percent / ZnCl2 / 5 h / 20 °C 3: 75 percent / NaBH3CN; TiCl4 / acetonitrile / 15 h / 0 °C 4: 61 percent / NaN(SiMe3)2 / tetrahydrofuran / 3 h / 20 °C 5: 100 percent / H2 / Pd/C / methanol / 15 h / 20 °C View Scheme
参考文献
Bioorganic and medicinal chemistry, , vol. 9, # 4 p. 1001 - 1011
反应条件
1: 69 percent / pyridine / 3 h / 110 °C 2: 94 percent / aq. TFA / 0.17 h / 20 °C 3: 80 percent / ZnCl2 / 5 h / 20 °C 4: 75 percent / NaBH3CN; TiCl4 / acetonitrile / 15 h / 0 °C 5: 61 percent / NaN(SiMe3)2 / tetrahydrofuran / 3 h / 20 °C 6: 100 percent / H2 / Pd/C / methanol / 15 h / 20 °C View Scheme
参考文献
Bioorganic and medicinal chemistry, , vol. 9, # 4 p. 1001 - 1011
反应条件
1: 1.) NaH / 1.) DMF, -5 deg C, 1.5 h, 2.) room temperature, 3 h 2: 90 percent / pyridine / 3 h / Ambient temperature 3: 80percent AcOH / 4 h / 90 °C 4: pyridine / 72 h / Ambient temperature 5: 1.) N,O-bis(trimethylsilyl)acetamide, 2.) TMS-triflate / 1.) CH3CN, room temperature, 1 h, 2.) 60 deg C, 2 h 6: 95 percent / NaOMe / methanol / 0.17 h / Ambient temperature 7: 1.) pTsCl, 2.) NaH / 1.) CH2Cl2, Py, -10 deg C, 3 h, 2.) DMF, 0 deg C, 12 h 8: 78 percent / H2 / Pd(OH)2/C / ethanol / 4 h View Scheme
参考文献
Tetrahedron, , vol. 54, # 14 p. 3607 - 3630
