4-溴-2-甲基-1-丁烯合成路线 （共 17 条）
反应条件
lithium bromide in N,N-dimethyl-formamide 2 h; Heating;
参考文献
Montero, Jean-Louis; Zgani, Ibrahim; Menut, Chantal; Gallois, Valerie
Patent: US2006/241087 A1, 2006 ;
Location in patent: Page/Page column 26-27 ;
反应条件
N-bromosuccinmide; triphenylphosphine in dichloromethane 3 h; Ambient temperature;
参考文献
Berkowitz, William F.; Wu, Yanzhong
Journal of Organic Chemistry, 1997 , vol. 62, # 5 p. 1536 - 1539
反应条件
lithium bromide in N,N-dimethyl-formamide T=20°C; Substitution; 24 h;
参考文献
Braddock, D. Christopher; Brown, John M.
Collection of Czechoslovak Chemical Communications, 2000 , vol. 65, # 5 p. 741 - 756
反应条件
Grubb's 2nd generation catalyst in chloroform-d1 T=40°C;
参考文献
Journal of Organic Chemistry, , vol. 75, # 20 p. 6908 - 6922
反应条件
Na2S2O4 in methylene chloride (CH2Cl2)
反应条件
1: 1.) Mg, 3.) aq. HCl 2: 1.) t-BuOH, Li, NH3(liquid), 3.) 4percent KOH View Scheme
参考文献
Paquette, Leo A.; Sauer, Daryl R.; Cleary, Darryl G.; Kinsella, Mary A.; Blackwell, Christopher M.; Anderson, Lawrence G.
Journal of the American Chemical Society, 1992 , vol. 114, # 19 p. 7375 - 7387
反应条件
1.1: LDA / tetrahydrofuran; hexane / 1 h / -20 °C 1.2: tetrahydrofuran; hexane / 2 h / -20 - 20 °C 2.1: 74 percent / aq. AcOH / 2 h / 20 °C 3.1: 38 percent / Me2AlCl / hexane / 24 h / -78 - 20 °C View Scheme
参考文献
Braddock, D. Christopher; Brown, John M.
Collection of Czechoslovak Chemical Communications, 2000 , vol. 65, # 5 p. 741 - 756
反应条件
1: lithium diisopropyl amide / tetrahydrofuran / -78 °C
2: lithium hydroxide hydrate / water
3: copper (I) cyanide / diethyl ether
View Scheme
参考文献
Huang, Jinhua; Yang, Jessica R.; Zhang, Jin; Yang, Jiong
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 19 p. 3212 - 3222
反应条件
1.1: (iPr)2NLi / tetrahydrofuran; hexane / -78 - 20 °C
1.2: tetrahydrofuran; hexane / 20 °C
2.1: NaIO4; phosphate buffer / H2O / 20 °C / pH 7.0
View Scheme
参考文献
Tokuyasu, Takahiro; Masuyama, Araki; Nojima, Masatomo; McCullough, Kevin J.
Journal of Organic Chemistry, 2000 , vol. 65, # 4 p. 1069 - 1075
反应条件
1: 1.) NaH, 2.) N-butyllithium
2: 1.) NaH / 1.) THF, -78 deg C, 2.) THF, from -78 deg C to RT
3: MeCu / tetrahydrofuran / 3 h / -25 °C
4: DIBAL / diethyl ether; hexane / 2 h / 0 °C
View Scheme
参考文献
Alderdice; Spino; Weiler
Canadian Journal of Chemistry, 1993 , vol. 71, # 11 p. 1955 - 1963
