6-溴-2-羟基于-甲氧基苯甲醛合成路线 （共 19 条）
反应条件
sodium hydrogencarbonate in methanol Deacetylation; 2 h;
参考文献
Journal of Medicinal Chemistry, , vol. 43, # 14 p. 2731 - 2737
反应条件
bromine; potassium bromide in water 1 h;
参考文献
Journal of Organic Chemistry, , vol. 52, # 20 p. 4485 - 4489
反应条件
1: 95 percent / Et3N / DMAP / CH2Cl2 / 2 h / 20 °C 2: 98 percent / KBr; Br2 / H2O / 10 h / 22 °C 3: 96 percent / NaHCO3 / methanol; H2O / 5 h / 20 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 44, # 27 p. 5129 - 5132
反应条件
sulfuric acid in ethanol; water 2 h; Heating; Yield given;
参考文献
Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, , vol. 41, # 10 p. 1273 - 1280
反应条件
1: Br2, Fe, CH3COONa / acetic acid / 16 h / Ambient temperature 2: conc. H2SO4 / ethanol; H2O / 2 h / Heating View Scheme
参考文献
Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, , vol. 41, # 10 p. 1273 - 1280
反应条件
1.1: 92 percent / NaBH4 / methanol / 1 h / 20 °C 2.1: 95 percent / aq. HBr / acetonitrile / 3 h / Heating 3.1: Et3N / toluene / Heating 4.1: n-BuLi / tetrahydrofuran; hexane / -90 °C 4.2: tetrahydrofuran; hexane / 20 °C View Scheme
参考文献
Hagihara, Koji; Kashima, Hajime; Iida, Kyoichiro; Enokizono, Junichi; Uchida, Shin-ichi; Nonaka, Hiromi; Kurokawa, Masako; Shimada, Junichi
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 6 p. 1616 - 1621
反应条件
1.1: 92 percent / NaBH4 / methanol / 1 h / 20 °C 2.1: 95 percent / aq. HBr / acetonitrile / 3 h / Heating 3.1: Et3N / toluene / Heating 4.1: n-BuLi / tetrahydrofuran; hexane / -90 °C 4.2: tetrahydrofuran; hexane / 20 °C View Scheme
参考文献
Hagihara, Koji; Kashima, Hajime; Iida, Kyoichiro; Enokizono, Junichi; Uchida, Shin-ichi; Nonaka, Hiromi; Kurokawa, Masako; Shimada, Junichi
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 6 p. 1616 - 1621
反应条件
1: 82 percent / aq. NaOH, H2O2 / 4 h / 25 °C 2: K2CO3, cupric oxide / 5.5 h / 110 °C 3: 1.) butyllithium / 1.) hexane, ether, from -20 deg C to -10 deg C, 30 min, 2.) hexane, ether, RT, 30 min View Scheme
参考文献
Simig, Gy.; Schlosser, M.
ACH - Models in Chemistry, 1994 , vol. 131, # 2 p. 217 - 228
反应条件
1: 77 percent / BBr3 / CH2Cl2 / 1.) 20 deg C, 2 h, 2.) room temp., 12 h 2: 62 percent / K2CO3, CuO / dimethylformamide / 4 h / 110 °C View Scheme
参考文献
Dallacker, Franz; Schleuter, Hans-Joachim; Schneider, Petra
Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, 1986 , vol. 41, # 10 p. 1273 - 1280
反应条件
1: 96 percent / K2CO3 / dimethylformamide / 5 h / 110 - 120 °C 2: 70 percent / KMnO4 / acetone; H2O / 3 h / 50 - 60 °C View Scheme
参考文献
Nimgirawath, Surachai; Ponghusabun, Ong-ard
Australian Journal of Chemistry, 1994 , vol. 47, # 5 p. 951 - 956
