2-氨基-5-(4-吡啶基)-1,3,4-噻重氮合成路线 （共 15 条）
反应条件
1: With PPA T=100°C; 2: With sodium hydroxide in water
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2004/41813 A1, 2004 ;
Location in patent: Page 102-103 ;
WO 2004/041813 A1
反应条件
trichlorophosphate T=0 - 5°C; 4.5 h; Reflux;
参考文献
Yu, Peng; Hu, Jun; Zhou, Tao-Yu; Wang, Peng; Xu, Yan-Hua
Journal of Chemical Research, 2011 , vol. 35, # 12 p. 703 - 706
反应条件
1: in ethanol Reflux; 2: With sulfuric acid in ethanol T=20°C;
参考文献
RSC Advances, , vol. 3, # 19 p. 6813 - 6816
参考文献
Farmaco, Edizione Scientifica, , vol. 13, p. 187,196
Yakugaku Zasshi, , vol. 74, p. 951
Chem.Abstr., , p. 10938
反应条件
hydrogenchloride in ethanol; water
反应条件
1.1: hydrogenchloride / water / Reflux 2.1: sulfuric acid / 2 h / 20 °C 2.2: 2 h / Cooling with ice View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 10, # 9 p. 1785 - 1794
反应条件
1: acetic acid anhydride 2: aqueous H2O2; acetic acid 3: aqueous HCl View Scheme
参考文献
Helvetica Chimica Acta, , vol. 41, p. 2058,2065
参考文献
Helvetica Chimica Acta, , vol. 41, p. 2058,2065
反应条件
1: ethanol; water; sodium acetate 2: acetic acid anhydride 3: aqueous H2O2; acetic acid 4: aqueous HCl View Scheme
参考文献
Helvetica Chimica Acta, , vol. 41, p. 2058,2065
反应条件
1: aqueous H2O2; acetic acid 2: aqueous HCl View Scheme
参考文献
Helvetica Chimica Acta, , vol. 41, p. 2058,2065
