5H,7H-二苯并[B,D]氮杂革-6-酮合成路线 （共 20 条）
反应条件
1: SOCl2 2: diethyl ether / Behandeln des Reaktionsprodukts mit Methanol unter Zusatz von Silberbenzoat und Triaethylamin 3: platinum; ethanol / Hydrogenation View Scheme
参考文献
Journal of the American Chemical Society, , vol. 77, p. 3393
反应条件
1: diethyl ether / Behandeln des Reaktionsprodukts mit Methanol unter Zusatz von Silberbenzoat und Triaethylamin 2: platinum; ethanol / Hydrogenation View Scheme
参考文献
Journal of the American Chemical Society, , vol. 77, p. 3393
反应条件
1.1: Pd(OAc)2; 4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 2-(dicyclohexylphosphino)biphenyl / dioxane / 1 h / 80 °C 1.2: 93 percent / Ba(OH)2*8H2O / dioxane; H2O / 1 h / 100 °C 2.1: 64 percent / NaOH / ethanol; H2O / 3 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 67, # 4 p. 1199 - 1207
反应条件
1: DIBALH / CH2Cl2 / -78 °C 2: NaClO2; 2-methyl-2-butene; NaH2PO4 / 2-methyl-propan-2-ol; H2O / 0 - 20 °C 3: 100 percent / DCC / CH2Cl2 / 20 °C 4: 76 percent / n-Bu3P / toluene / 20 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 45, # 11 p. 2323 - 2326
反应条件
1: 100 percent / DCC / CH2Cl2 / 20 °C 2: 76 percent / n-Bu3P / toluene / 20 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 45, # 11 p. 2323 - 2326
反应条件
trifluorormethanesulfonic acid T=100°C;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 22 p. 6392 - 6395
反应条件
1.1: triethylamine / dichloromethane / 2 h / 20 °C / |Inert atmosphere 2.1: n-butyllithium / tetrahydrofuran / 0 - 23 °C / |Inert atmosphere 2.2: |Inert atmosphere View Scheme
参考文献
Angewandte Chemie - International Edition, , vol. 52, # 8 p. 2194 - 2197
Angew. Chem., , vol. 125, # 8 p. 2250 - 2253,4
反应条件
1: NaH / dimethylformamide / 0 - 20 °C 2: n-BuONO; KHMDS / tetrahydrofuran / 0 °C 3: Zn; TFA / CH2Cl2 / 20 °C View Scheme
参考文献
Fuwa, Haruhiko; Okamura, Yumiko; Morohashi, Yuichi; Tomita, Taisuke; Iwatsubo, Takeshi; Kan, Toshiyuki; Fukuyama, Tohru; Natsugari, Hideaki
Tetrahedron Letters, 2004 , vol. 45, # 11 p. 2323 - 2326
反应条件
1: 5,7-dihydro-dibenz[b,d]azepin-6-one With sodium hydride in N,N-dimethyl-formamide; mineral oil T=0 - 25°C; Inert atmosphere; 2: methyl iodide in N,N-dimethyl-formamide; mineral oil T=25°C; 1 h; Inert atmosphere;
参考文献
Tabata, Hidetsugu; Suzuki, Hiroyuki; Akiba, Kumi; Takahashi, Hideyo; Natsugari, Hideaki
Journal of Organic Chemistry, 2010 , vol. 75, # 17 p. 5984 - 5993
