5H,7H-二苯并[B,D]氮杂革-6-酮合成路线 （共 20 条）
反应条件
AlCl3, aluminium chloride in 2,4-dichloro-benzene T=170°C; 24 h;
参考文献
Hoffmann-Emery, Fabienne; Jakob-Roetne, Roland
Patent: US2008/293933 A1, 2008 ;
Location in patent: Page/Page column 5 ;
反应条件
1: With tetrakis(triphenylphosphine) palladium(0); caesium carbonate in ethylene glycol dimethyl ether T=125°C; 0.5 h; Microwave irradiationInert atmosphereSealed tube; 2: With potassium tert-butylate in tetrahydrofuran; ethylene glycol dimethyl ether T=0 - 20°C; 0.166667 h; Inert atmosphereSealed tube; Reagent/catalystSolvent;
参考文献
Deb, Prasant K.; Sharma, Somesh; Borude, Avinash; Singh, Ravi P.; Kumar, Deepak; Reddy, L. Krishnakanth
Tetrahedron Letters, 2013 , vol. 54, # 23 p. 2916 - 2919
反应条件
sodium hydroxide in methanol; water T=90°C; 8 h;
参考文献
Tabata, Hidetsugu; Suzuki, Hiroyuki; Akiba, Kumi; Takahashi, Hideyo; Natsugari, Hideaki
Journal of Organic Chemistry, 2010 , vol. 75, # 17 p. 5984 - 5993
反应条件
1,10-phenanthroline; potassium tert-butylate in benzene T=81°C; 24 h;
参考文献
Bhakuni, Bhagat Singh; Shrimali, Kaustubh; Kumar, Amit; Kumar, Sangit
Organic Syntheses, 2013 , vol. 90, p. 164 - 173
反应条件
1: With n-butyllithium in tetrahydrofuran T=0 - 23°C; Inert atmosphere; 2: With iodine in tetrahydrofuran Inert atmosphere;
参考文献
Jeffrey, Jenna L.; Bartlett, Emily S.; Sarpong, Richmond
Angewandte Chemie - International Edition, 2013 , vol. 52, # 8 p. 2194 - 2197
Angew. Chem., 2013 , vol. 125, # 8 p. 2250 - 2253,4
反应条件
sodium hydroxide in ethanol; water 3 h; Heating;
参考文献
Baudoin, Olivier; Cesario, Michele; Guenard, Daniel; Gueritte, Francoise
Journal of Organic Chemistry, 2002 , vol. 67, # 4 p. 1199 - 1207
反应条件
1,10-phenanthroline; potassium tert-butylate in benzene T=110°C; 36 h;
参考文献
Organic Letters, , vol. 14, # 11 p. 2838 - 2841
反应条件
1.1: pinacolborane; Et3N; 2-(dicyclohexylphosphino)biphenyl / Pd(OAc)2 / dioxane / 80 °C 1.2: 100 percent / aq. Ba(OH)2*8H2O / dioxane / 100 °C 2.1: NaNO2; aq. HCl / tetrahydrofuran / 0 °C 2.2: NaN3 / tetrahydrofuran / 0 - 20 °C 3.1: DIBALH / CH2Cl2 / -78 °C 4.1: NaClO2; 2-methyl-2-butene; NaH2PO4 / 2-methyl-propan-2-ol; H2O / 0 - 20 °C 5.1: 100 percent / DCC / CH2Cl2 / 20 °C 6.1: 76 percent / n-Bu3P / toluene / 20 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 45, # 11 p. 2323 - 2326
反应条件
1.1: pinacolborane; Et3N; 2-(dicyclohexylphosphino)biphenyl / Pd(OAc)2 / dioxane / 80 °C 1.2: 100 percent / aq. Ba(OH)2*8H2O / dioxane / 100 °C 2.1: NaNO2; aq. HCl / tetrahydrofuran / 0 °C 2.2: NaN3 / tetrahydrofuran / 0 - 20 °C 3.1: DIBALH / CH2Cl2 / -78 °C 4.1: NaClO2; 2-methyl-2-butene; NaH2PO4 / 2-methyl-propan-2-ol; H2O / 0 - 20 °C 5.1: 100 percent / DCC / CH2Cl2 / 20 °C 6.1: 76 percent / n-Bu3P / toluene / 20 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 45, # 11 p. 2323 - 2326
反应条件
ethanol; platinum Hydrogenation;
参考文献
Journal of the American Chemical Society, , vol. 77, p. 3393
