1-(3-氯苯基)-4-甲基-哌嗪合成路线 (共 4 条)
反应条件
1,1-dimethylpropan-1-ol; sodium hydride; [2,2']bipyridinyl; nickel diacetate in tetrahydrofuran 0.5 h; Heating;
参考文献
Desmarets, Christophe; Schneider, Raphael; Fort, Yves
Tetrahedron Letters, 2001 , vol. 42, # 2 p. 247 - 250
反应条件
formic acid Heating;
参考文献
Romanelli; Manetti; Scapecchi; Borea; Dei; Bartolini; Ghelardini; Gualtieri; Guandalini; Varani
Journal of Medicinal Chemistry, 2001 , vol. 44, # 23 p. 3946 - 3955
反应条件
potassium carbonate; potassium iodide in acetone 8 h; Ambient temperature;
参考文献
Mokrosz; Pietrasiewicz; Duszynska; Cegla
Journal of Medicinal Chemistry, 1992 , vol. 35, # 13 p. 2369 - 2374
反应条件
styrene; [2,2']bipyridinyl; sodium tert-pentoxide; sodium hydride; nickel in tetrahydrofuran Condensation; 10 h; Heating; Product distribution; Further Variations:other reaction time, various contents of Ni(0);
参考文献
Brenner, Eric; Schneider, Raphael; Fort, Yves
Tetrahedron, 1999 , vol. 55, # 44 p. 12829 - 12842