7-溴-2,3-二氢-异吲哚-1-酮合成路线 （共 6 条）
反应条件
1: With N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile in benzene T=25°C; 8 h; Heating / reflux; 2: With ammonia in tetrahydrofuran; water T=25°C; 4 h;
参考文献
JANSSEN PHARMACEUTICA, N.V.
Patent: WO2007/47646 A2, 2007 ;
Location in patent: Page/Page column 52-53 ;
WO 2007/047646 A2
反应条件
ammonia in ethanol Heating / reflux;
参考文献
WO2006/21805 A1, ;
Page/Page column 87 ;
WO 2006/021805 A1
反应条件
ammonium hydroxide in tetrahydrofuran 18 h; Ambient temperature; Yield given;
参考文献
Heterocycles, , vol. 45, # 11 p. 2217 - 2221
反应条件
1: thionyl chloride / 1 h / 60 °C 2: Et3N / 1 h / 0 °C 3: NBS, AIBN / benzene / 18 h / Heating 4: ammonium hydroxide / tetrahydrofuran / 18 h / Ambient temperature View Scheme
参考文献
Heterocycles, , vol. 45, # 11 p. 2217 - 2221
反应条件
1: Et3N / 1 h / 0 °C 2: NBS, AIBN / benzene / 18 h / Heating 3: ammonium hydroxide / tetrahydrofuran / 18 h / Ambient temperature View Scheme
参考文献
Heterocycles, , vol. 45, # 11 p. 2217 - 2221
反应条件
palladium diacetate; sodium carbonate; tris-(o-tolyl)phosphine in water; N,N-dimethyl-formamide
Suzuki coupling;
参考文献
Hughes, Terry V.; Emanuel, Stuart L.; O'Grady, Harold R.; Connolly, Peter J.; Rugg, Catherine; Fuentes-Pesquera, Angel R.; Karnachi, Prabha; Alexander, Richard; Middleton, Steven A.
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 18 p. 5130 - 5133
