2-苯基-4,5-二氢-噻唑-4-羧酸合成路线 （共 2 条）
反应条件
1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.17 h / 20 °C 1.2: 20 °C 2.1: trichloromonobromomethane; 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 0 - 20 °C 3.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / -78 - -20 °C View Scheme
参考文献
Lu, Yan; Li, Chien-Ming; Wang, Zhao; Chen, Jianjun; Mohler, Michael L.; Li, Wei; Dalton, James T.; Miller, Duane D.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 13 p. 4678 - 4693
反应条件
ethyl acetate; dicyclohexyl-carbodiimide in 1,4-dioxane
参考文献
Kishore,V. et al.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1977 , vol. 15, p. 255 - 257
