6-氯-2-(三氟甲基)-9h-嘌呤合成路线 （共 9 条）
反应条件
thionyl chloride; N,N-dimethyl-formamide in chloroform 1.5 h; Heating;
参考文献
Kelley; Linn; Selway
Journal of Medicinal Chemistry, 1989 , vol. 32, # 8 p. 1757 - 1763
反应条件
1: 2: With thionyl chloride
参考文献
MEMORY PHARMACEUTICALS CORPORATION
Patent: WO2004/14911 A1, 2004 ;
Location in patent: Page 43 ;
WO 2004/014911 A1
反应条件
potassium carbonate in N,N-dimethyl-formamide 1.5 h; Ambient temperature;
参考文献
Kelley, James L.; Linn, James A.
Journal of Organic Chemistry, 1986 , vol. 51, # 26 p. 5435 - 5436
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20°C; 23 h; Inert atmosphere;
参考文献
Roggen, Heidi; Gundersen, Lise-Lotte
European Journal of Organic Chemistry, 2008 , # 30 p. 5099 - 5106
反应条件
potassium carbonate in DMF (N,N-dimethyl-formamide) T=20°C; 16 h;
参考文献
MEMORY PHARMACEUTICALS CORPORATION
Patent: WO2004/14913 A2, 2004 ;
Location in patent: Page 74 ;
WO 2004/014913 A2
反应条件
potassium carbonate in (2S)-N-methyl-1-phenylpropan-2-amine hydrate; N,N-dimethyl-formamide
参考文献
MEMORY PHARMACEUTICALS CORP.
Patent: US2003/45533 A1, 2003 ;
US 20030045533 A1
反应条件
potassium carbonate in dimethyl sulfoxide
参考文献
Bourguignon; Desaubry; Raboisson; Wermuth; Lugnier
Journal of Medicinal Chemistry, 1997 , vol. 40, # 12 p. 1768 - 1770
参考文献
Kelley; Linn; Selway
Journal of Medicinal Chemistry, 1989 , vol. 32, # 8 p. 1757 - 1763
反应条件
1: 83 percent / ethanol / 66 h 2: 72 percent / K2CO3 / dimethylformamide / 48 h / Ambient temperature View Scheme
参考文献
Kelley; Linn; Selway
Journal of Medicinal Chemistry, 1989 , vol. 32, # 8 p. 1757 - 1763
