3,4-二氢-2(1H)-异喹啉羰基氯化物合成路线 （共 22 条）
反应条件
1: methyllithium With CuCN in tetrahydrofuran T=-30°C; 0.5 h; 2: 1,2,3,4-tetrahydroisoquinolin-2-ylcarbonyl chloride in tetrahydrofuran T=-30 - 0°C; 2 h;
参考文献
Organic Letters, , vol. 6, # 21 p. 3703 - 3706
反应条件
pyridine in dichloromethane
T=20°C; 2 h;
参考文献
Lemoucheux, Laurent; Rouden, Jacques; Ibazizene, Meziane; Sobrio, Franck; Lasne, Marie-Claire
Journal of Organic Chemistry, 2003 , vol. 68, # 19 p. 7289 - 7297
反应条件
in dichloromethane
1 h;
参考文献
Lemoucheux, Laurent; Rouden, Jacques; Ibazizene, Meziane; Sobrio, Franck; Lasne, Marie-Claire
Journal of Organic Chemistry, 2003 , vol. 68, # 19 p. 7289 - 7297
反应条件
in dichloromethane
T=20°C; 0.5 h;
参考文献
Lemoucheux, Laurent; Rouden, Jacques; Ibazizene, Meziane; Sobrio, Franck; Lasne, Marie-Claire
Journal of Organic Chemistry, 2003 , vol. 68, # 19 p. 7289 - 7297
反应条件
triethylamine in tetrahydrofuran; toluene
T=-78°C; 1 h;
参考文献
Zhang, Pingsheng; Gawley, Robert E.
Tetrahedron Letters, 1992 , vol. 33, # 21 p. 2945 - 2948
反应条件
in dichloromethane
21 h;
参考文献
Lemoucheux, L.; Rouden, J.; Ibazizene, M.; Sobrio, F.; Lasne, M.-C.
Journal of Labelled Compounds and Radiopharmaceuticals, 2001 , vol. 44, p. S128 - S131
反应条件
1: NaOH / toluene; H2O / 12 h / 20 °C
2: 2.48 g / LiAlH4 / tetrahydrofuran / 36 h / Heating
3: 3 percent Spectr. / diethyl ether / 1 h / 20 °C
View Scheme
参考文献
Lemoucheux, Laurent; Rouden, Jacques; Ibazizene, Meziane; Sobrio, Franck; Lasne, Marie-Claire
Journal of Organic Chemistry, 2003 , vol. 68, # 19 p. 7289 - 7297
反应条件
in tetrahydrofuran
1 h;
参考文献
Lemoucheux, L.; Rouden, J.; Ibazizene, M.; Sobrio, F.; Lasne, M.-C.
Journal of Labelled Compounds and Radiopharmaceuticals, 2001 , vol. 44, p. S128 - S131
反应条件
1: 62 percent / LiAlH4 / tetrahydrofuran / Heating
2: 100 percent Spectr. / tetrahydrofuran / 1 h / 20 °C
View Scheme
参考文献
Lemoucheux, Laurent; Rouden, Jacques; Ibazizene, Meziane; Sobrio, Franck; Lasne, Marie-Claire
Journal of Organic Chemistry, 2003 , vol. 68, # 19 p. 7289 - 7297
反应条件
1: 2.48 g / LiAlH4 / tetrahydrofuran / 36 h / Heating
2: 3 percent Spectr. / diethyl ether / 1 h / 20 °C
View Scheme
参考文献
Lemoucheux, Laurent; Rouden, Jacques; Ibazizene, Meziane; Sobrio, Franck; Lasne, Marie-Claire
Journal of Organic Chemistry, 2003 , vol. 68, # 19 p. 7289 - 7297
