7-甲氧基-6-(3-吗啉-4-基丙氧基)喹唑啉-4(3H)-酮合成路线 （共 22 条）
反应条件
ammonia in hydrogenchloride
反应条件
1: With formamide T=20 - 100°C; 2: T=100°C; 7 h;
参考文献
Wang, Ji-Quan; Gao, Mingzhang; Miller, Kathy D.; Sledge, George W.; Zheng, Qi-Huang
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 15 p. 4102 - 4106
反应条件
in ethanol 4 h; Reflux;
参考文献
Journal of Chemical Research, , # 6 p. 388 - 390
参考文献
Shih, Kae-Shyang; Hsieh, Yu-Jung; Liu, Ching-Wei
Patent: US2010/267949 A1, 2010 ;
Location in patent: Page/Page column 7 ;
反应条件
1: 4-methoxy-5-[3-(4-morpholinyl)propoxy]-2-nitrobenzonitrile With iron(III) chloride; hydrazine hydrate in methanol; water 3 h; Heating; 2: formic acid With hydrogenchloride in water T=90 - 130°C; Further stages.;
参考文献
Chandregowda, Venkateshappa; Venkateswara Rao, Gudapati; Chandrasekara Reddy, Goukanapalli
Heterocycles, 2007 , vol. 71, # 1 p. 39 - 48
反应条件
1: With ammonium cerium (IV) nitrate; acetic acid in water 2: With sodium hydroxide in water
参考文献
Marzaro, Giovanni; Guiotto, Adriano; Pastorini, Giovanni; Chilin, Adriana
Tetrahedron, 2010 , vol. 66, # 4 p. 962 - 968
反应条件
in 2-methoxy-ethanol 8 h; Heating;
参考文献
Journal of Heterocyclic Chemistry, , vol. 45, # 3 p. 703 - 708
反应条件
1: 76 percent / potassium carbonate / acetone / 24 h / Heating 2: 82 percent / nitric acid; trifluoroacetic acid / CH2Cl2 / 2 h / 20 °C 3: 60 percent / 1 h / 100 °C 4: hydrogen / palladium on activated carbon / methanol 5: 78 percent / 2-methoxy-ethanol / 2 h / 115 °C View Scheme
参考文献
Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 48, # 11 p. 829 - 843
反应条件
1: 82 percent / nitric acid; trifluoroacetic acid / CH2Cl2 / 2 h / 20 °C 2: 60 percent / 1 h / 100 °C 3: hydrogen / palladium on activated carbon / methanol 4: 78 percent / 2-methoxy-ethanol / 2 h / 115 °C View Scheme
参考文献
Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 48, # 11 p. 829 - 843
反应条件
1: 60 percent / 1 h / 100 °C 2: hydrogen / palladium on activated carbon / methanol 3: 78 percent / 2-methoxy-ethanol / 2 h / 115 °C View Scheme
参考文献
Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 48, # 11 p. 829 - 843
