2-(2-氨基-5-甲基-苯基)-1,1,1,3,3,3-六氟-2-丙醇合成路线 （共 5 条）
反应条件
toluene-4-sulfonic acid in water; chlorobenzene T=100°C; 5 h;
参考文献
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM); UNIVERSITE DE NANTES; CHU NANTES; GESTIN, Jean-Francois; GUERARD, Francois; FAIVRE-CHAUVET, Alain
Patent: WO2011/95517 A1, 2011 ;
Location in patent: Page/Page column 21-22 ;
反应条件
bromine in tetrachloromethane
参考文献
Nguyen, Tuyen T.; Martin, J. C.
Journal of the American Chemical Society, 1980 , vol. 102, # 24 p. 7382 - 7383
反应条件
1: With sulfuric acid; sodium nitrite in water
T=0°C;
2: With potassium iodide in water
T=80°C; Cooling with ice;
参考文献
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM); UNIVERSITE DE NANTES; CHU NANTES; GESTIN, Jean-Francois; GUERARD, Francois; FAIVRE-CHAUVET, Alain
Patent: WO2011/95517 A1, 2011 ;
Location in patent: Page/Page column 22 ;
反应条件
1.1: sodium nitrite; sulfuric acid / water / 0 °C
1.2: 80 °C / Cooling with ice
2.1: N-bromosuccinmide / isopropyl alcohol / 0.5 h / 50 °C
View Scheme
参考文献
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM); UNIVERSITE DE NANTES; CHU NANTES; GESTIN, Jean-Francois; GUERARD, Francois; FAIVRE-CHAUVET, Alain
Patent: WO2011/95517 A1, 2011 ;
反应条件
1.1: sodium nitrite; sulfuric acid / water / 0 °C
1.2: 80 °C / Cooling with ice
2.1: hydrogenchloride; sodium hypochlorite / isopropyl alcohol; water / 0.08 h / 20 °C
View Scheme
参考文献
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM); UNIVERSITE DE NANTES; CHU NANTES; GESTIN, Jean-Francois; GUERARD, Francois; FAIVRE-CHAUVET, Alain
Patent: WO2011/95517 A1, 2011 ;
