(S)-1-Boc-3-羟甲基吡咯烷合成路线 （共 11 条）
反应条件
hydrogen; palladium hydroxide on carbon in methanol T=50°C; P=2585.81 Torr;
参考文献
WO2007/100670 A1, ;
Page/Page column 51 ;
WO 2007/100670 A1
反应条件
1: (3S)-3-({[tert-butyl(dimethyl)silyl]oxy}methyl)-1-[(1R)-1-phenylethyl]pyrrolidine With 1-chloroethyl chlorocarbonate in 1,2-dichloro-ethane 5 h; Reflux; 2: With N-ethyl-N,N-diisopropylamine in 1,2-dichloro-ethane 3 h; Reflux; 3: di-tert-butyl dicarbonate With potassium carbonate in tetrahydrofuran; water T=0°C; 3 h;
参考文献
WO2011/19090 A1, ;
Page/Page column 45-46 ;
WO 2011/019090 A1
反应条件
[((R,R)-3,5-t-Bu-salen)Co(III)(OTf)] in tert-butyl methyl ether T=40°C; 72 h; optical yield given as percent eeenantioselective reaction;
参考文献
Journal of the American Chemical Society, , vol. 131, p. 2786 - 2787
反应条件
1: With borane in tetrahydrofuran T=0 - 20°C; 4 h; 2: With hydrogenchloride; water in tetrahydrofuran T=0°C;
参考文献
US2010/298334 A1, ;
Page/Page column 68 ;
US 20100298334 A1
反应条件
hydrogen; palladium dihydroxide in methanol; water
参考文献
Journal of Medicinal Chemistry, , vol. 40, # 22 p. 3497 - 3500
反应条件
Resolution of racemate;
参考文献
WO2004/108677 A1, ;
Page 138 ;
WO 2004/108677 A1
反应条件
1.1: methanol / 18 h / 20 °C 1.2: 16 h / Reflux 2.1: lithium aluminium tetrahydride / CPME / 1.25 h / 0 - 20 °C / Inert atmosphere 2.2: 0 °C 3.1: 1H-imidazole / N,N-dimethyl-formamide / 0 - 20 °C 4.1: 1-chloroethyl chlorocarbonate / 1,2-dichloro-ethane / 5 h / Reflux 4.2: 3 h / Reflux 4.3: 3 h / 0 °C View Scheme
参考文献
WO2011/19090 A1, ;
WO 2011/019090 A1
反应条件
1.1: 1H-imidazole / N,N-dimethyl-formamide / 0 - 20 °C 2.1: 1-chloroethyl chlorocarbonate / 1,2-dichloro-ethane / 5 h / Reflux 2.2: 3 h / Reflux 2.3: 3 h / 0 °C View Scheme
参考文献
WO2011/19090 A1, ;
WO 2011/019090 A1
反应条件
1.1: lithium aluminium tetrahydride / CPME / 1.25 h / 0 - 20 °C / Inert atmosphere 1.2: 0 °C 2.1: 1H-imidazole / N,N-dimethyl-formamide / 0 - 20 °C 3.1: 1-chloroethyl chlorocarbonate / 1,2-dichloro-ethane / 5 h / Reflux 3.2: 3 h / Reflux 3.3: 3 h / 0 °C View Scheme
参考文献
WO2011/19090 A1, ;
WO 2011/019090 A1
反应条件
1H-imidazole; iodine; triphenylphosphine in dichloromethane T=70°C; 3 h;
参考文献
DAINIPPON SUMITOMO PHARMA CO., LTD.; MIZUNO, Kazuhiro; IKEDA, Junya; NAKAMURA, Takanori; IWATA, Masato; OTAKA, Hiromichi; GOTO, Nana
Patent: WO2012/169649 A1, 2012 ;
Location in patent: Page/Page column 164; 165 ;
WO 2012/169649 A1
