Alpha-甲基-4-硝基苯乙酸合成路线 （共 24 条）
反应条件
hydrogenchloride in water T=20°C; 14 h; Heating / reflux; Product distribution / selectivity;
参考文献
Gruenenthal GmbH
Patent: US2009/156590 A1, 2009 ;
Location in patent: Page/Page column 62; 63; 64; 65 ;
US 20090156590 A1
反应条件
potassium hydroxide in tetrahydrofuran; methanol 6 h;
参考文献
Journal of Organic Chemistry, , vol. 51, # 10 p. 1704 - 1712
反应条件
hydrogenchloride; sodium hydroxide; NaH in nitrobenzene; N,N-dimethyl-formamide; mineral oil
反应条件
sodium hydroxide in methanol; water; N,N-dimethyl-formamide T=50°C; 1 h;
参考文献
Journal of Medicinal Chemistry, , vol. 26, # 2 p. 222 - 226
反应条件
1: SO2Cl / 1 h / 60 °C 2: CH2Cl2 / 1 h / 40 °C 3: 1.) NaNH2 / 1.) toluene, RT, 10 min, 2.) toluene, RT, 40 min 4: H20, ethan. KOH / ethanol / 24 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 37, # 11 p. 1704 - 1711
反应条件
1: CH2Cl2 / 1 h / 40 °C 2: 1.) NaNH2 / 1.) toluene, RT, 10 min, 2.) toluene, RT, 40 min 3: H20, ethan. KOH / ethanol / 24 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 37, # 11 p. 1704 - 1711
反应条件
1: 1.) NaH / 1.) DMF, 50 deg C, 20 min, 2.) DMF, 100 deg C, 2 h 2: NaOH / dimethylformamide; methanol; H2O / 1 h / 50 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 26, # 2 p. 222 - 226
反应条件
nitric acid in dichloromethane 24 h; Ambient temperature;
参考文献
Journal of Organic Chemistry, , vol. 63, # 4 p. 952 - 958
反应条件
1: fuming nitric acid 2: concentrated hydrochloric acid View Scheme
参考文献
Chemische Berichte, , vol. 49, p. 2280
反应条件
nitric acid Reaktion ueber mehrere Stufen;
参考文献
Justus Liebigs Annalen der Chemie, , vol. 227, p. 274
