5-苄氧基-2-(4-苄氧基-苯基)-3-甲基-1-[4-(2-氮杂环庚烷-1-基-乙氧基)-苄基]-1H-吲哚合成路线 （共 25 条）
反应条件
hydrogen; 2.34 Pd/C in tetrahydrofuran; ethanol 5 h;
参考文献
Jirman, Josef; Richter, Jindrich
Patent: US2010/240888 A1, 2010 ;
Location in patent: Page/Page column 5 ;
反应条件
1: 5-(benzyloxy)-2-(4-(benzyloxy)phenyl)-3-methyl-1H-indole With sodium hydride in N,N-dimethyl-formamide
T=0 - 5°C; Inert atmosphere;
2: 1-(2-(4-(chloromethyl)phenoxy)ethyl)azepane hydrochloride in N,N-dimethyl-formamide
Inert atmosphere;
参考文献
Jirman, Josef; Richter, Jindrich
Patent: US2010/240888 A1, 2010 ;
Location in patent: Page/Page column 3 ;
反应条件
sodium hydroxide in water; toluene
T=65 - 70°C; 1.5 h;
参考文献
DIVI'S LABORATORIES LIMITED
Patent: US2012/330008 A1, 2012 ;
Location in patent: Page/Page column 9 ;
反应条件
in toluene
T=70 - 75°C; 12 h;
参考文献
DIVI'S LABORATORIES LIMITED
Patent: US2012/330008 A1, 2012 ;
Location in patent: Page/Page column 9 ;
反应条件
in toluene
T=70 - 75°C; 12 h;
参考文献
DIVI'S LABORATORIES LIMITED
Patent: US2012/330008 A1, 2012 ;
Location in patent: Page/Page column 9 ;
反应条件
in toluene
T=70 - 75°C; 12 h;
参考文献
DIVI'S LABORATORIES LIMITED
Patent: US2012/330008 A1, 2012 ;
Location in patent: Page/Page column 9 ;
反应条件
1.1: K2CO3
2.1: SOCl2 / tetrahydrofuran
3.1: sodium hydride / dimethylformamide / 0.33 h / 0 °C
3.2: 59 percent / dimethylformamide / 18 h / 20 °C
4.1: 78 percent / LiAlH4 / tetrahydrofuran / 0.5 h / 0 °C
5.1: 87 percent / CBr4; Ph3P / tetrahydrofuran / 3 h / 20 °C
6.1: tetrahydrofuran
View Scheme
参考文献
Miller; Collini; Tran; Harris; Kharode; Marzolf; Moran; Henderson; Bender; Unwalla; Greenberger; Yardley; Abou-Gharbia; Lyttle; Komm
Journal of Medicinal Chemistry, 2001 , vol. 44, # 11 p. 1654 - 1657
反应条件
1.1: 51 percent / Et3N / dimethylformamide / Heating
2.1: sodium hydride / dimethylformamide / 0.33 h / 0 °C
2.2: 59 percent / dimethylformamide / 18 h / 20 °C
3.1: 78 percent / LiAlH4 / tetrahydrofuran / 0.5 h / 0 °C
4.1: 87 percent / CBr4; Ph3P / tetrahydrofuran / 3 h / 20 °C
5.1: tetrahydrofuran
View Scheme
参考文献
Miller; Collini; Tran; Harris; Kharode; Marzolf; Moran; Henderson; Bender; Unwalla; Greenberger; Yardley; Abou-Gharbia; Lyttle; Komm
Journal of Medicinal Chemistry, 2001 , vol. 44, # 11 p. 1654 - 1657
反应条件
1.1: 51 percent / Et3N / dimethylformamide / Heating
2.1: sodium hydride / dimethylformamide / 0.33 h / 0 °C
2.2: 59 percent / dimethylformamide / 18 h / 20 °C
3.1: 78 percent / LiAlH4 / tetrahydrofuran / 0.5 h / 0 °C
4.1: 87 percent / CBr4; Ph3P / tetrahydrofuran / 3 h / 20 °C
5.1: tetrahydrofuran
View Scheme
参考文献
Miller; Collini; Tran; Harris; Kharode; Marzolf; Moran; Henderson; Bender; Unwalla; Greenberger; Yardley; Abou-Gharbia; Lyttle; Komm
Journal of Medicinal Chemistry, 2001 , vol. 44, # 11 p. 1654 - 1657
反应条件
1.1: sodium hydride / dimethylformamide / 0.33 h / 0 °C
1.2: 59 percent / dimethylformamide / 18 h / 20 °C
2.1: 78 percent / LiAlH4 / tetrahydrofuran / 0.5 h / 0 °C
3.1: 87 percent / CBr4; Ph3P / tetrahydrofuran / 3 h / 20 °C
4.1: tetrahydrofuran
View Scheme
参考文献
Miller; Collini; Tran; Harris; Kharode; Marzolf; Moran; Henderson; Bender; Unwalla; Greenberger; Yardley; Abou-Gharbia; Lyttle; Komm
Journal of Medicinal Chemistry, 2001 , vol. 44, # 11 p. 1654 - 1657
