N,N'-dimethyl-barbituric acid; tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran T=65°C; 12 h;

1: 35 percent / toluene / 2 h / 110 °C 2: 95 percent / NEt3 / dimethylformamide / 4 h 3: 76 percent / Na2CO3 / PdCl2(dppf) / dimethylformamide; H2O / 1 h / 100 °C 4: 63 percent / 1,3-dimethylbarbituric acid / Pd(PPh3)4 / tetrahydrofuran / 12 h / 65 °C View Scheme

1: 95 percent / NEt3 / dimethylformamide / 4 h 2: 76 percent / Na2CO3 / PdCl2(dppf) / dimethylformamide; H2O / 1 h / 100 °C 3: 63 percent / 1,3-dimethylbarbituric acid / Pd(PPh3)4 / tetrahydrofuran / 12 h / 65 °C View Scheme

1: Fe; AcOH / ethanol / 4 h / 110 °C 2: 35 percent / toluene / 2 h / 110 °C 3: 95 percent / NEt3 / dimethylformamide / 4 h 4: 76 percent / Na2CO3 / PdCl2(dppf) / dimethylformamide; H2O / 1 h / 100 °C 5: 63 percent / 1,3-dimethylbarbituric acid / Pd(PPh3)4 / tetrahydrofuran / 12 h / 65 °C View Scheme

1: Na2CO3 / acetonitrile / 24 h / 80 °C 2: Fe; AcOH / ethanol / 4 h / 110 °C 3: 35 percent / toluene / 2 h / 110 °C 4: 95 percent / NEt3 / dimethylformamide / 4 h 5: 76 percent / Na2CO3 / PdCl2(dppf) / dimethylformamide; H2O / 1 h / 100 °C 6: 63 percent / 1,3-dimethylbarbituric acid / Pd(PPh3)4 / tetrahydrofuran / 12 h / 65 °C View Scheme

T=200°C; 64 h;