4,6-二羟基-2-甲巯基嘧啶合成路线 （共 15 条）
反应条件
1.1: trichlorophosphate / 4 h / 120 °C 2.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 3 h / -78 °C 2.2: 0.5 h / 20 °C 2.3: 20 °C / pH 1 View Scheme
参考文献
ABBOTT LABORATORIES; VASUDEVAN, Anil; PENNING, Thomas; CHEN, Huanming; LIANG, Bo; WANG, Shaohui; WU, Fengchun; SHEN, Yan; LIU, Cuihua; ZOU, Zhenguang
Patent: WO2012/97478 A1, 2012 ;
反应条件
1: N,N-dimethyl-formamide With trichlorophosphate in 1,1,2-trichloroethylene T=5 - 20°C; 2: 2,4-dihydroxy-2-methylmercaptopyrimidine (zwitterionic form) in 1,1,2-trichloroethylene T=80°C;
参考文献
WO2006/104889 A2, ;
Page/Page column 113-114 ;
WO 2006/104889 A2
反应条件
trichlorophosphate in 1,1,2-trichloroethylene T=5 - 80°C;
参考文献
WO2007/147104 A2, ;
Page/Page column 78-79 ;
WO 2007/147104 A2
反应条件
1: N,N-dimethyl-formamide With trichlorophosphate T=-5 - 20°C; 1 h; 2: 2-methylmercapto-4,6-dihydroxypyrimidine T=20°C; 3.5 h; Heating / reflux;
参考文献
WO2007/84560 A2, ;
Page/Page column 105-106 ;
反应条件
1.1: trichlorophosphate / 4 h / 120 °C 2.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 3 h / -78 °C 2.2: 0.5 h / 20 °C 2.3: 20 °C / pH 1 3.1: thionyl chloride / 1 h / Reflux 3.2: 2 h / 0 - 20 °C View Scheme
参考文献
ABBOTT LABORATORIES; VASUDEVAN, Anil; PENNING, Thomas; CHEN, Huanming; LIANG, Bo; WANG, Shaohui; WU, Fengchun; SHEN, Yan; LIU, Cuihua; ZOU, Zhenguang
Patent: WO2012/97478 A1, 2012 ;
反应条件
1: POCl3 2: methanol View Scheme
参考文献
Luethy, Christoph; Zondler, Helmut; Rapold, Thomas; Seifert, Gottfried; Urwyler, Bernhard; Heinis, Thomas; Steinruecken, Hans Christian; Allen, James
Pest Management Science, 2001 , vol. 57, # 3 p. 205 - 224
反应条件
sodium hydroxide Ambient temperature;
参考文献
Ishizumi; Kojima; Antoku
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 9 p. 2288 - 2300
反应条件
nitric acid T=0°C; 2 h;
参考文献
Brinkman, John A.; Cheung, Adrian Wai-Hing; Firooznia, Fariborz; Guertin, Kevin Richard; Marcopulos, Nicholas; Qi, Lida; Racha, Jagdish Kumar; Sarabu, Ramakanth; Tan, Jenny; Tilley, Jefferson Wright
Patent: US2007/270433 A1, 2007 ;
Location in patent: Page/Page column 51 ;
US 20070270433 A1
反应条件
1: POCl3 2: methanol 3: H2O2 in situ View Scheme
参考文献
Luethy, Christoph; Zondler, Helmut; Rapold, Thomas; Seifert, Gottfried; Urwyler, Bernhard; Heinis, Thomas; Steinruecken, Hans Christian; Allen, James
Pest Management Science, 2001 , vol. 57, # 3 p. 205 - 224
反应条件
1: nitric acid / 2 h / Cooling with ice 2: N,N-diethylaniline; trichlorophosphate / 1 h / Cooling with ice; Reflux View Scheme
参考文献
JANSSEN RandD IRELAND; BONFANTI, Jean-François; DOUBLET, Frédéric Marc Maurice; EMBRECHTS, Werner; FORTIN, Jérôme Michel Claude; MC GOWAN, David Craig; MULLER, Philippe; RABOISSON, Pierre Jean-Marie Bernard
Patent: WO2013/68438 A1, 2013 ;
