2-(甲基硫代)-5-硝基嘧啶-4,6-二醇合成路线 （共 4 条）
反应条件
nitric acid T=0°C; 2 h;
参考文献
Brinkman, John A.; Cheung, Adrian Wai-Hing; Firooznia, Fariborz; Guertin, Kevin Richard; Marcopulos, Nicholas; Qi, Lida; Racha, Jagdish Kumar; Sarabu, Ramakanth; Tan, Jenny; Tilley, Jefferson Wright
Patent: US2007/270433 A1, 2007 ;
Location in patent: Page/Page column 51 ;
US 20070270433 A1
反应条件
sodium hydroxide 2.) RT, 1 h; Yield given. Multistep reaction;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2008/135785 A1, 2008 ;
Location in patent: Page/Page column 69 ;
WO 2008/135785 A1
反应条件
N,N-diethylaniline; trichlorophosphate 1 h; Heating / reflux;
参考文献
Brinkman, John A.; Cheung, Adrian Wai-Hing; Firooznia, Fariborz; Guertin, Kevin Richard; Marcopulos, Nicholas; Qi, Lida; Racha, Jagdish Kumar; Sarabu, Ramakanth; Tan, Jenny; Tilley, Jefferson Wright
Patent: US2007/270433 A1, 2007 ;
Location in patent: Page/Page column 51 ;
US 20070270433 A1
反应条件
1: N,N-dimethyl-aniline; trichlorophosphate / 0 - 100 °C
2: ammonia; triethylamine / tetrahydrofuran; isopropyl alcohol / 20 °C / |Cooling
View Scheme
参考文献
JANSSEN RandD IRELAND; BONFANTI, Jean-François; FORTIN, Jérôme Michel Claude; MULLER, Philippe; DOUBLET, Frédéric Marc Maurice; RABOISSON, Pierre Jean-Marie Bernard; ARNOULT, Eric Pierre Alexandre
Patent: WO2014/9509 A1, 2014 ;
