2-甲硫基-4,6-二氯-5-硝基嘧啶合成路线 (共 5 条)
反应条件
N,N-diethylaniline; trichlorophosphate 1 h; Heating / reflux;
参考文献
Brinkman, John A.; Cheung, Adrian Wai-Hing; Firooznia, Fariborz; Guertin, Kevin Richard; Marcopulos, Nicholas; Qi, Lida; Racha, Jagdish Kumar; Sarabu, Ramakanth; Tan, Jenny; Tilley, Jefferson Wright
Patent: US2007/270433 A1, 2007 ;
Location in patent: Page/Page column 51 ;
US 20070270433 A1
反应条件
1: nitric acid / 2 h / Cooling with ice 2: N,N-diethylaniline; trichlorophosphate / 1 h / Cooling with ice; Reflux View Scheme
参考文献
Hammarstroem, Lars G.J; Smith, David B; Talamas, Francisco X; Labadie, Sharada S; Krauss, Nancy E
Tetrahedron Letters, 2002 , vol. 43, # 45 p. 8071 - 8073
反应条件
ammonia; triethylamine in tetrahydrofuran; isopropyl alcohol
T=20°C; Cooling;
参考文献
JANSSEN RandD IRELAND; BONFANTI, Jean-François; DOUBLET, Frédéric Marc Maurice; EMBRECHTS, Werner; FORTIN, Jérôme Michel Claude; MC GOWAN, David Craig; MULLER, Philippe; RABOISSON, Pierre Jean-Marie Bernard
Patent: WO2013/68438 A1, 2013 ;
Location in patent: Page/Page column 30 ;
反应条件
ammonia; triethylamine in tetrahydrofuran
T=-20 - 0°C; 1.5 h;
参考文献
Gilead Sciences, Inc.
Patent: US2010/143301 A1, 2010 ;
Location in patent: Page/Page column 46 ;