1-氟-3-[(E)-2-硝基乙烯基]苯合成路线 （共 4 条）
反应条件
ammonium acetate in acetic acid T=20 - 100°C; Inert atmosphere;
参考文献
Lopchuk, Justin M.; Hughes, Russell P.; Gribble, Gordon W.
Organic Letters, 2013 , vol. 15, # 20 p. 5218 - 5221
反应条件
palladium (II) trifluoroacetate; silver(I) acetate in ethylene glycol dimethyl ether; dimethyl sulfoxide T=100°C; 24 h; GloveboxSchlenk techniqueInert atmosphere; Overall yield = 55 percent; regioselective reaction;
参考文献
Zhang, Min; Hu, Peng; Zhou, Jun; Wu, Ge; Huang, Shijun; Su, Weiping
Organic Letters, 2013 , vol. 15, # 7 p. 1718 - 1721
反应条件
CuCl2·2H2O; 3-chloro-benzenecarboperoxoic acid T=0 - 60°C; Henry Nitro Aldol Condensation; 10 h; Inert atmosphere;
参考文献
Liu, Jia; Zhu, Xiao-Rui; Ren, Jiangmeng; Chen, Wei-Dong; Zeng, Bu-Bing
Synlett, 2013 , vol. 24, # 20 art. no. ST-2013-W0735-L, p. 2740 - 2742
反应条件
1: sodium hydroxide; water / methanol / -10 - 0 °C 2: 4-(N,N-dimethlyamino)pyridine; acetic anhydride / 0 - 20 °C View Scheme
参考文献
MERCK PATENT GMBH; HUCK, Bayard R.; CHEN, Xiaoling; NEAGU, Constantin; JONES, Reinaldo; XIAO, Yufang; MOCHALKIN, Igor
Patent: WO2012/16001 A1, 2012 ;
WO 2012/016001 A1
