(3,5-二甲基-4-异恶唑基)甲醇合成路线 （共 14 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0 - 20°C;
参考文献
TEMPERO PHARMACEUTICALS, INC.; BALOGLU, Erkan; GHOSH, Shomir; LOBERA, Mercedes; SCHMIDT, Darby, R.
Patent: WO2013/19626 A1, 2013 ;
Location in patent: Page/Page column 26 ;
WO 2013/019626 A1
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 1.) 0 deg C, 2.) room temperature;
参考文献
Natale, Nicholas R.; Quincy, David A.
Synthetic Communications, 1983 , vol. 13, # 10 p. 817 - 822
反应条件
methanol; sodium tetrahydroborate T=0 - 20°C;
参考文献
WO2010/132999 A1, ;
Page/Page column 109 ;
反应条件
hydrogenchloride T=65 - 70°C;
参考文献
Journal of Heterocyclic Chemistry, , vol. 29, # 6 p. 1557 - 1560
参考文献
Zhurnal Obshchei Khimii, , vol. 28, p. 2736,2743; engl. Ausg. S. 2762, 2768
反应条件
1: ZnCl2; HCl; 1,2-dichloro-ethane 2: lead (II)-oxide-hydrate View Scheme
参考文献
Zhurnal Obshchei Khimii, , vol. 28, p. 2736,2743; engl. Ausg. S. 2762, 2768
反应条件
barium permanganate in benzene 3 h; Heating;
参考文献
Mirzaei; Bavili-Tabrizi; Hashemi-Gohare; Zare-Neirizi; Edjlali
Organic Preparations and Procedures International, 2003 , vol. 35, # 2 p. 207 - 214
反应条件
1: Dess-Martin periodane / dichloromethane / 1.17 h / 0 - 20 °C 2: tetrahydrofuran; diethyl ether / 1.67 h / 0 - 20 °C 3: pyridinium chlorochromate / dichloromethane / 1 h / 0 - 20 °C View Scheme
参考文献
TEMPERO PHARMACEUTICALS, INC.; BALOGLU, Erkan; BOHNERT, Gary, J.; GHOSH, Shomir; LOBERA, Mercedes; SCHMIDT, Darby, R.; SUNG, Leonard
Patent: WO2013/19682 A1, 2013 ;
WO 2013/019682 A1
反应条件
thionyl chloride in dichloromethane 1.5 h; Ambient temperature;
参考文献
Journal of Heterocyclic Chemistry, , vol. 29, # 6 p. 1557 - 1560
