1: With 4-(N,N-dimethlyamino)pyridine in N,N-dimethyl-formamide 2: With (NH4)2CO3 in N,N-dimethyl-formamide T=75 - 80°C; 5 h; 3: With hydrogenchloride in water; N,N-dimethyl-formamide

1.1: 53 percent / Et3N; 4-(dimethylamino)pyridine / dimethylformamide 2.1: 4-(dimethylamino)pyridine / dimethylformamide 2.2: 62 percent / HCl / dimethylformamide 3.1: ammonium carbonate / dimethylformamide / 5 h / 75 - 80 °C 3.2: 81 percent / HCl / dimethylformamide View Scheme