1-(3 -羟丙基)吡咯烷合成路线 （共 16 条）
反应条件
potassium carbonate in tetrahydrofuran T=20°C; 15 h;
参考文献
BANYU PHARMACEUTICAL CO., LTD.
Patent: EP1852423 A1, 2007 ;
Location in patent: Page/Page column 6; 14 ;
EP 1852423 A1
反应条件
potassium carbonate in acetonitrile
参考文献
Hennequin, Laurent Francois Andre
Patent: US2003/212055 A1, 2003 ;
反应条件
lithium aluminium tetrahydride in diethyl ether T=20°C; 2 h;
参考文献
Le Sann, Christine; Huddleston, Jonathan; Mann, John
Tetrahedron, 2007 , vol. 63, # 52 p. 12903 - 12911
反应条件
diisobutylaluminium hydride in toluene Ring cleavage; reduction; Heating;
参考文献
Bergmann, David J.
Australian Journal of Chemistry, 1999 , vol. 52, # 12 p. 1131 - 1138
反应条件
lithium aluminium tetrahydride in diethyl ether 11 h; Heating;
参考文献
Gribble; Switzer; Soll
Journal of Organic Chemistry, 1988 , vol. 53, # 14 p. 3164 - 3170
反应条件
1: 33 percent / H2 / [Rh(OAc)2]2; BIPHEPHOS / benzene / 20 h / 80 °C / 20701.7 Torr 2: 60 percent / 1.5 M DIBAL-H / toluene / Heating View Scheme
参考文献
Australian Journal of Chemistry, , vol. 52, # 12 p. 1131 - 1138
反应条件
triphenylphosphine; ruthenium trichloride T=220°C; 15 h;
参考文献
Journal of Organometallic Chemistry, , vol. 373, p. 343 - 352
反应条件
1: 100 percent / 25percent aq. NaOH / methanol / 2 h / Ambient temperature 2: 1.) 5 M aq. HCl / 1.) RT, 90 min, 2.) pH = 5.5, RT, 4 h 3: NaBH3CN / 1.17 h View Scheme
参考文献
Journal of Organic Chemistry, , vol. 53, # 14 p. 3164 - 3170
反应条件
potassium carbonate; sodium iodide in ethanol 12 h; Reflux;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 17, # 6 p. 2607 - 2622
反应条件
1: 1.) 5 M aq. HCl / 1.) RT, 90 min, 2.) pH = 5.5, RT, 4 h 2: NaBH3CN / 1.17 h View Scheme
参考文献
Journal of Organic Chemistry, , vol. 53, # 14 p. 3164 - 3170
