1.1: sodium hydroxide; water / ethanol / 17 h / 80 °C 1.2: pH 2 2.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 12 h / 20 °C 3.1: sodium tetrahydroborate; acetic acid / 1,4-dioxane / 3.5 h / 10 - 105 °C 4.1: hydrogenchloride / water / 30 °C 4.2: 1 h / 0 - 20 °C 4.3: 1 h 5.1: sodium hydroxide / ethanol; water / 0.5 h / 60 °C / Inert atmosphere 5.2: 12 h / 60 °C / Inert atmosphere 6.1: toluene / 24 h / 120 °C 7.1: hydrogenchloride / ethanol / 1.5 h / 80 °C / Reflux 7.2: pH 14 View Scheme

1.1: sodium hydroxide; water / ethanol / 17 h / 80 °C 1.2: pH 2 2.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 12 h / 20 °C 3.1: sodium tetrahydroborate / 1,4-dioxane / 0.17 h / 10 °C 3.2: 3.5 h / 10 - 105 °C View Scheme

1: With water; sodium hydroxide in ethanol T=80°C; 17 h; 2: With hydrogenchloride in water pH=2;

1.1: sodium hydroxide; water / ethanol / 17 h / 80 °C 1.2: pH 2 2.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 12 h / 20 °C 3.1: sodium tetrahydroborate; acetic acid / 1,4-dioxane / 3.5 h / 10 - 105 °C 4.1: hydrogenchloride / water / 30 °C 4.2: 1 h / 0 - 20 °C 4.3: 1 h 5.1: sodium hydroxide / ethanol; water / 0.5 h / 60 °C / Inert atmosphere 5.2: 12 h / 60 °C / Inert atmosphere View Scheme