3,4-二甲基-1H-吡咯-2-羧醛合成路线 （共 16 条）
反应条件
1: SO2Cl2; diethyl ether / Erwaermen des Reaktionsprodukts mit H2O 2: aqueous KOH-solution 3: hydrogen chloride; diethyl ether 4: water; NaOH-solution View Scheme
参考文献
Fischer; Hoefelmann
Justus Liebigs Annalen der Chemie, 1938 , vol. 533, p. 216,229
反应条件
1: Raney nickel; ethanol / 160 °C / 110326 Torr / Hydrogenation 2: SO2Cl2; diethyl ether / Erwaermen des Reaktionsprodukts mit H2O 3: aqueous KOH-solution 4: hydrogen chloride; diethyl ether 5: water; NaOH-solution View Scheme
参考文献
Fischer; Hoefelmann
Justus Liebigs Annalen der Chemie, 1938 , vol. 533, p. 216,229
反应条件
1: aqueous KOH-solution 2: hydrogen chloride; diethyl ether 3: water; NaOH-solution View Scheme
参考文献
Fischer; Hoefelmann
Justus Liebigs Annalen der Chemie, 1938 , vol. 533, p. 216,229
反应条件
1,3-dibromo-5,5-dimethyl-hydantoin in tetrahydrofuran T=-78 - 20°C; 5 h; Inert atmosphere;
参考文献
Kancharla, Papireddy; Reynolds, Kevin A.
Tetrahedron, 2013 , vol. 69, # 39 p. 8375 - 8385
反应条件
1.1: aq. hydroxylamine O-sulfonic acid
1.2: O-mesitylenesulfonylhydroxylamine
1.3: NaH / CH2Cl2
2.1: aq. KOH
View Scheme
参考文献
Hunt, John T.; Mitt, Toomas; Borzilleri, Robert; Gullo-Brown, Johnni; Fargnoli, Joseph; Fink, Brian; Han, Wen-Ching; Mortillo, Steven; Vite, Gregory; Wautlet, Barri; Wong, Tai; Yu, Chiang; Zheng, Xiaoping; Bhide, Rajeev
Journal of Medicinal Chemistry, 2004 , vol. 47, # 16 p. 4054 - 4059
反应条件
dihydrogen peroxide; sodium hydrogencarbonate in methanol
T=20°C;
参考文献
Coffin, Aaron R.; Roussell, Michael A.; Tserlin, Elina; Pelkey, Erin T.
Journal of Organic Chemistry, 2006 , vol. 71, # 17 p. 6678 - 6681
