1: EtONa / ethanol / 7 h / -15 °C 2: toluene / 14 h / Heating View Scheme

Stage #1: <a href="#" onclick="return RXDsubstances(event, this, '605365', constants.ctx, '0')">DMFA</a> <b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '956581', constants.ctx, '0')">phosphoryl chloride</a> <br />T=10&deg;C;&nbsp;0.333333&nbsp;h;&nbsp;<br />Stage #2: <a href="#" onclick="return RXDsubstances(event, this, '117859', constants.ctx, '0')">1,3-dimethylindole</a>; <a href="#" onclick="return RXDsubstances(event, this, '605365', constants.ctx, '0')">DMFA</a> T=98 - 100&deg;C;&nbsp;3&nbsp;h;&nbsp;<br />Stage #3: <b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '3595639', constants.ctx, '0')">sodium acetate</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '3587155', constants.ctx, '0')">water</a> <br />T=28&deg;C;&nbsp;0.5&nbsp;h;&nbsp;<br /> <br /> &nbsp;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '11342940', constants.ctx, '0')">sodium hydroxide</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '956581', constants.ctx, '0')">trichlorophosphate</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '3587155', constants.ctx, '0')">water</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '605365', constants.ctx, '0')">N,N-dimethyl-formamide</a> <br /> <br /> <br /> &nbsp;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '3564799', constants.ctx, '0')">ammonium acetate</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '3587155', constants.ctx, '0')">water</a> <br />T=150&deg;C;&nbsp;30&nbsp;h;&nbsp;&nbsp;Inert atmosphereSealed tube;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1.1: NaH / dimethylformamide<br />1.2: dimethylformamide<br />2.1: POCl₃ <br /> <br /> &nbsp;