2,2'-联吡啶-5-羧酸合成路线 （共 9 条）
反应条件
potassium permanganate in water T=90°C; 6 h;
参考文献
Killeen, J. Scott; Browne, Wesley R.; Skupin, Marc; Fuhrhop, Juergen-Hinrich; Vos, Johannes G.
New Journal of Chemistry, 2003 , vol. 27, # 7 p. 1078 - 1083
反应条件
sodium hydroxide in tetrahydrofuran; methanol 16 h; Heating;
参考文献
Shaffer, Christopher J.; Schroeder, Detlef; Guetz, Christoph; Luetzen, Arne
Angewandte Chemie - International Edition, 2012 , vol. 51, # 32 p. 8097 - 8100
反应条件
sodium hydroxide in methanol 3 h; Ambient temperature;
参考文献
Ghadiri, M. Reza; Soares, Christopher; Choi, Chong
Journal of the American Chemical Society, 1992 , vol. 114, # 3 p. 825 - 831
反应条件
1: 84 percent / (PPh3)2PdCl2 / m-xylene / 7 h / 135 °C 2: 80 percent / aq. NaOH / methanol / 20 °C View Scheme
参考文献
Nakamura, Motomi; Tsutsumi, Mayuka; Ishikawa, Yoshiaki; Umemiya, Haruka; Izawa, Kazumi; Abe, Haruka; Togashi, Yosuke; Kinone, Tatsuya; Sekiguchi, Sho; Igumi, Mihiro; Ide, Kanako; Hasegawa, Teruaki; Hasegawa, Toki
Tetrahedron, 2013 , vol. 69, # 14 p. 3019 - 3026
反应条件
1: 93 percent / NH4OAc / formamide / 1.) 60 deg C, 4 h, 2.) r.t., 16 h 2: 59 percent / KMnO4 / H2O / Heating View Scheme
参考文献
Filby, Maria H.; Muldoon, James; Dabb, Serin; Fletcher, Nicholas C.; Ashcroft, Alison E.; Wilson, Andrew J.
Chemical Communications, 2011 , vol. 47, # 1 p. 559 - 561
反应条件
1: 84 percent / (PPh3)2PdCl2 / m-xylene / 7 h / 135 °C 2: 80 percent / aq. NaOH / methanol / 20 °C View Scheme
参考文献
Nakamura, Motomi; Tsutsumi, Mayuka; Ishikawa, Yoshiaki; Umemiya, Haruka; Izawa, Kazumi; Abe, Haruka; Togashi, Yosuke; Kinone, Tatsuya; Sekiguchi, Sho; Igumi, Mihiro; Ide, Kanako; Hasegawa, Teruaki; Hasegawa, Toki
Tetrahedron, 2013 , vol. 69, # 14 p. 3019 - 3026
反应条件
1: Pd(Ph3P)2Cl2 / tetrahydrofuran / 20 h / Heating 2: 95 percent / 1N NaOH / methanol / 3 h / Ambient temperature View Scheme
参考文献
Ghadiri, M. Reza; Soares, Christopher; Choi, Chong
Journal of the American Chemical Society, 1992 , vol. 114, # 3 p. 825 - 831
反应条件
1: pyridine; iodine / 4 h / 80 °C 2: ammonium acetate; formamide / 6 h / 80 °C 3: potassium permanganate; water / 5 h / 70 °C View Scheme
参考文献
Filby, Maria H.; Muldoon, James; Dabb, Serin; Fletcher, Nicholas C.; Ashcroft, Alison E.; Wilson, Andrew J.
Chemical Communications, 2011 , vol. 47, # 1 p. 559 - 561
反应条件
1.1: tert.-butyl lithium / tetrahydrofuran; pentane / 0.5 h / -78 °C / Inert atmosphere 1.2: 2.5 h / -78 - 20 °C / Inert atmosphere 1.3: 18 h / Inert atmosphere; Reflux 2.1: sodium hydroxide / tetrahydrofuran; methanol; water / 18 h / 20 °C / Inert atmosphere; Reflux 2.2: 48 h / 4 °C / Inert atmosphere View Scheme
参考文献
Shaffer, Christopher J.; Schroeder, Detlef; Guetz, Christoph; Luetzen, Arne
Angewandte Chemie - International Edition, 2012 , vol. 51, # 32 p. 8097 - 8100
