2,5-二溴-3-苯基噻吩合成路线 （共 6 条）
反应条件
methanol; tetrabutylammomium bromide; bromine in dichloromethane T=20°C;
参考文献
Mellah; Labbe; Nedelec; Perichon
New Journal of Chemistry, 2001 , vol. 25, # 2 p. 318 - 321
反应条件
1.1: Mg anode; ZnX2 / Ni / dimethylformamide / 20 °C / Electrochemical reaction 1.2: Pd / dimethylformamide 2.1: 95 percent / tetrabutylammonium bromide; methanol; Br2 / CH2Cl2 / 20 °C View Scheme
参考文献
Al-Taweel, Samir A.; Al-Saraierh, Hassan F.
Phosphorus, Sulfur and Silicon and Related Elements, 1999 , vol. 155, p. 47 - 57
反应条件
1.1: [1,3-bis(diphenylphosphino) propane] dichloronickel(II) / tetrahydrofuran / 0.17 h / Reflux 1.2: 2 h / 20 °C / Reflux 2.1: N-bromosuccinmide; acetic acid / ethanol; water; toluene / 0 - 20 °C / Inert atmosphere; Darkness View Scheme
参考文献
Gothard, Chris M.; Soh, Siowling; Gothard, Nosheen A.; Kowalczyk, Bartlomiej; Wei, Yanhu; Baytekin, Bilge; Grzybowski, Bartosz A.
Angewandte Chemie - International Edition, 2012 , vol. 51, # 32 p. 7922 - 7927
反应条件
1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / ethanol; water; toluene / 12 h / 60 °C / Inert atmosphere 2: N-bromosuccinmide; acetic acid / ethanol; water; toluene / 0 - 20 °C / Inert atmosphere; Darkness View Scheme
参考文献
Gothard, Chris M.; Soh, Siowling; Gothard, Nosheen A.; Kowalczyk, Bartlomiej; Wei, Yanhu; Baytekin, Bilge; Grzybowski, Bartosz A.
Angewandte Chemie - International Edition, 2012 , vol. 51, # 32 p. 7922 - 7927
反应条件
1: thien-2-yl bromide With magnesium in diethyl ether 3 h; Heating; 2: 2,5-Dibromo-3-phenylthiophene With [1,3-bis(diphenylphosphino) propane] dichloronickel(II) in diethyl ether Kumada-type cross-coupling reaction; 75 h; Heating;
参考文献
Mitschke, Ullrich; Baeuerle, Peter
Journal of the Chemical Society. Perkin Transactions 1, 2001 , # 7 p. 740 - 753
反应条件
1: 81 percent / bromine / CH2Cl2 / 8 h / 50 °C 2: 92 percent / n-BuLi / diethyl ether / 2 h / -70 °C View Scheme
参考文献
Sotgiu, Giovanna; Zambianchi, Massimo; Barbarella, Giovanna; Aruffo, Fabio; Cipriani, Franco; Ventola, Alfredo
Journal of Organic Chemistry, 2003 , vol. 68, # 4 p. 1512 - 1520
