1: (R)-cysteine; N,N-dimethyl-2-thiohistidine With ammonia in water
pH=4.5 - 5;
2: benzaldehyde in water
T=20°C; 15 h;
3: With ammonia in water
pH=6; Purification / work up;
1: 93 percent / Et3N / dimethylformamide / 2 h / Ambient temperature
2: 81 percent / pyridine / dimethylformamide / 2 h / Ambient temperature
3: 85 percent / NH3 / methanol / 1.5 h / Ambient temperature
View Scheme
参考文献
Pavlova, L. A.; Komarova, T. V.; Davidovich, Yu. A.; Rogozhin, S. V.; Puchkova, S. M.; Tuzhilkova, T. N.
Pharmaceutical Chemistry Journal, 1986 , vol. 20, # 9 p. 653 - 658
Khimiko-Farmatsevticheskii Zhurnal, 1986 , vol. 20, # 9 p. 1083 - 1088
1.1: triethylamine / tetrahydrofuran / -10 - 20 °C
1.2: 80 percent / tetrahydrofuran / -10 - 20 °C
2.1: 32 percent / acetic anhydride / 2 h / 200 °C
View Scheme
参考文献
Pinho E Melo, Teresa M. V. D.; Gomes, Clara S. B.; Soares, Maria I. L.; Rocha Gonsalves, Antonio M. D'A.; Paixao, Jose A.; Beja, Ana M.; Ramos Silva, Manuela
Journal of Heterocyclic Chemistry, 2004 , vol. 41, # 4 p. 493 - 497
