2,8-二甲基-2,3,4,5-四氢-1H-吡啶并[4,3-b]吲哚合成路线 （共 21 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran Inert atmosphereReflux;
参考文献
AUSPEX PHARMACEUTICALS, INC.
Patent: US2010/125085 A1, 2010 ;
Location in patent: Page/Page column 14 ;
US 20100125085 A1
反应条件
1: With hydrogenchloride in water T=20 - 55°C; 2: With sodium hydroxide in tert-butyl methyl ether; water T=5 - 45°C; pH=3.2 - 12.4; Product distribution / selectivity;
参考文献
MEDIVATION NEUROLOGY, INC.
Patent: WO2009/111540 A1, 2009 ;
Location in patent: Page/Page column 26 ;
反应条件
in ethanol T=80°C; 16 h;
参考文献
MEDIVATION TECHNOLOGIES, INC.
Patent: WO2009/55828 A1, 2009 ;
Location in patent: Page/Page column 250 ;
WO 2009/055828 A1
反应条件
L-(+)-tartaric acid-urea melt T=90°C; Fischer Indole Synthesis;
参考文献
Gore, Sangram; Baskaran, Sundarababu; Koenig, Burkhard
Organic Letters, 2012 , vol. 14, # 17 p. 4568 - 4571
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0°C; 4 h;
参考文献
Lv, Jinglei; Li, Ji; Zhang-Negrerie, Daisy; Shang, Siyun; Gao, Qingzhi; Du, Yunfei; Zhao, Kang
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 12 p. 1929 - 1932
反应条件
sodium tetrahydroborate in methanol; water T=20 - 100°C; Inert atmosphere;
参考文献
Dong, Huijun; Latka, Regina T.; Driver, Tom G.
Organic Letters, 2011 , vol. 13, # 10 p. 2726 - 2729
反应条件
potassium tert-butylate; KNH2 in tetrahydrofuran T=0 - 60°C; Fischer Indole Synthesis; 24 h; Inert atmosphere; Product distribution / selectivity;
参考文献
WO2011/139242 A2, ;
Page/Page column 9 ;
反应条件
1: dichloromethane / 20 °C / Inert atmosphere 2: dirhodium(II) tetrakis(perfluorobutyrate) / toluene / 15 h / 90 °C / Inert atmosphere; Molecular sieve 3: sodium tetrahydroborate / methanol; water / 20 - 100 °C / Inert atmosphere View Scheme
参考文献
Organic Letters, , vol. 13, # 10 p. 2726 - 2729
反应条件
1: dirhodium(II) tetrakis(perfluorobutyrate) / toluene / 15 h / 90 °C / Inert atmosphere; Molecular sieve 2: sodium tetrahydroborate / methanol; water / 20 - 100 °C / Inert atmosphere View Scheme
参考文献
Organic Letters, , vol. 13, # 10 p. 2726 - 2729
反应条件
1.1: acetic acid; sodium nitrite / water / 1.5 h / 0 °C / Inert atmosphere 1.2: 0 - 20 °C / Inert atmosphere 2.1: dichloromethane / 20 °C / Inert atmosphere 3.1: dirhodium(II) tetrakis(perfluorobutyrate) / toluene / 15 h / 90 °C / Inert atmosphere; Molecular sieve 4.1: sodium tetrahydroborate / methanol; water / 20 - 100 °C / Inert atmosphere View Scheme
参考文献
Organic Letters, , vol. 13, # 10 p. 2726 - 2729
