1: With trifluoroacetic acid 1.5 h; Heating / reflux; 2: With ammonia in methanol; water pH=11;

1: propan-2-ol / 4 h / Heating 2: TFA / 0.83 h / Heating View Scheme

1.1: dioxane / 24 h / Heating 1.2: 84 percent / NaOAc; AcOH / 3 h / Heating 2.1: SOCl2; DMF / Heating 3.1: propan-2-ol / 4 h / Heating 4.1: TFA / 0.83 h / Heating View Scheme

1: SOCl2; DMF / Heating 2: propan-2-ol / 4 h / Heating 3: TFA / 0.83 h / Heating View Scheme

1.1: oxalyl dichloride / toluene / 2 h / Reflux 1.2: 2 h 2.1: acetic acid / 0.17 h / 90 °C 2.2: 1 h / Reflux 3.1: 1,4-dioxane / 12 h / Reflux 3.2: 3 h / Reflux 4.1: thionyl chloride; trichlorophosphate / N,N-dimethyl-formamide / 2 h / Reflux 5.1: isopropyl alcohol / 2 h / Reflux 6.1: trifluoroacetic acid / 2 h / Heating View Scheme

1.1: potassium permanganate / acetone / 2 h / 30 - 50 °C 2.1: oxalyl dichloride / toluene / 2 h / Reflux 2.2: 2 h 3.1: acetic acid / 0.17 h / 90 °C 3.2: 1 h / Reflux 4.1: 1,4-dioxane / 12 h / Reflux 4.2: 3 h / Reflux 5.1: thionyl chloride; trichlorophosphate / N,N-dimethyl-formamide / 2 h / Reflux 6.1: isopropyl alcohol / 2 h / Reflux 7.1: trifluoroacetic acid / 2 h / Heating View Scheme

1.1: acetic acid / 0.17 h / 90 °C 1.2: 1 h / Reflux 2.1: 1,4-dioxane / 12 h / Reflux 2.2: 3 h / Reflux 3.1: thionyl chloride; trichlorophosphate / N,N-dimethyl-formamide / 2 h / Reflux 4.1: isopropyl alcohol / 2 h / Reflux 5.1: trifluoroacetic acid / 2 h / Heating View Scheme

1.1: nitric acid / 2 h / 0 - 20 °C 2.1: potassium permanganate / acetone / 2 h / 30 - 50 °C 3.1: oxalyl dichloride / toluene / 2 h / Reflux 3.2: 2 h 4.1: acetic acid / 0.17 h / 90 °C 4.2: 1 h / Reflux 5.1: 1,4-dioxane / 12 h / Reflux 5.2: 3 h / Reflux 6.1: thionyl chloride; trichlorophosphate / N,N-dimethyl-formamide / 2 h / Reflux 7.1: isopropyl alcohol / 2 h / Reflux 8.1: trifluoroacetic acid / 2 h / Heating View Scheme

1: hydrogenchloride / isopropyl alcohol / 2 h / Reflux 2: trifluoroacetic acid / 1 h / Reflux View Scheme

1: N-ethyl-N,N-diisopropylamine; trichlorophosphate / dichloromethane 2: potassium carbonate / tetrahydrofuran View Scheme