(2R)-2-氨基-3-甲氧基-n-(苯基甲基)丙酰胺合成路线 （共 15 条）
反应条件
1: With water; sodium hydroxide; tetrabutylammomium bromide in dichloromethane T=-10 - -5°C; 2: With hydrogenchloride in dichloromethane; water T=25 - 30°C; 2 h;
参考文献
WO2012/14226 A1, ;
Page/Page column 19-20 ;
反应条件
hydrogen; palladium(II) oxide hydrate in methanol T=25 - 30°C; P=3677.86 Torr; 8 h; Inert atmosphere;
参考文献
WO2011/144983 A2, ;
Page/Page column 30 ;
反应条件
hydrogen; palladium on activated charcoal in methanol 3 h; Ambient temperature;
参考文献
Tetrahedron Asymmetry, , vol. 9, # 21 p. 3841 - 3854
反应条件
palladium 10 on activated carbon; hydrogen in ethyl acetate T=30 - 35°C; P=3750.38 - 4500.45 Torr; 1 h;
参考文献
US2010/240926 A1, ;
Page/Page column 6 ;
反应条件
hydrogenchloride in dichloromethane; water 1 h;
参考文献
WO2006/37574 A1, ;
Page/Page column 18-19 ;
反应条件
1: With hydrogenchloride in dichloromethane; water T=20°C; 0.5 h; 2: With ammonia in water
参考文献
EP2067765 A2, ;
Page/Page column 13 ;
反应条件
1: With hydrogenchloride in water Reflux; 2: With sodium hydroxide in water pH=8 - 9;
参考文献
US2012/283466 A1, ;
Page/Page column 6 ;
反应条件
1: 90 percent / Ag2O / acetonitrile / 20 °C 2: 96 percent / H2 / Pd/C / methanol / 4 h / 20 °C / 760 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 45, # 21 p. 4762 - 4773
反应条件
1.1: 4-methyl-morpholine; isobutyl chloroformate / dichloromethane / -5 °C 1.2: -5 - 0 °C 2.1: potassium hydroxide / dichloromethane / 5 °C 2.2: 5 °C 3.1: hydrogenchloride / dichloromethane; water / 25 - 30 °C 3.2: 25 - 30 °C / pH 10 - 11 View Scheme
反应条件
1.1: potassium hydroxide / dichloromethane / 5 °C 1.2: 5 °C 2.1: hydrogenchloride / dichloromethane; water / 25 - 30 °C 2.2: 25 - 30 °C / pH 10 - 11 View Scheme
