6-氯-1(3h)-异苯并呋喃酮合成路线 （共 14 条）
反应条件
1: N-bromosuccinimide, α,α'-azobisisobutyronitrile / CCl4 / 1 h / Heating
2: benzene / 24 h / 90 - 95 °C
3: 36.6 percent / triethylamine / CH2Cl2 / 2 h
4: iodine
View Scheme
参考文献
Sakamoto; Ikeda; Tsukamoto
Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 8 p. 2698 - 2707
反应条件
N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile in tetrachloromethane
T=0°C; 3 h; RefluxInert atmosphere;
参考文献
Fronert, Jeanne; Bisschops, Tom; Cassens-Sasse, Elisa; Atodiresei, Iuliana; Enders, Dieter
Synthesis (Germany), 2013 , vol. 45, # 12 art. no. SS-2013-Z0289-OP, p. 1708 - 1712
反应条件
in N-methyl-acetamide
参考文献
SmithKline Corporation
Patent: US4086350 A1, 1978 ;
反应条件
ammonium chloride in diethyl ether; benzene
参考文献
Gruppo Lepetit S.p.A.
Patent: US3985811 A1, 1976 ;
