6-氯-1(3h)-异苯并呋喃酮合成路线 （共 14 条）
反应条件
ammonium chloride in diethyl ether; benzene
反应条件
palladium diacetate; potassium hydrogencarbonate
T=140°C; 36 h;
参考文献
Zhang, Yang-Hui; Shi, Bing-Feng; Yu, Jin-Quan
Angewandte Chemie, International Edition, 2009 , vol. 48, # 33 p. 6097 - 6100
Angewandte Chemie, 2009 , vol. 121, # 33 p. 6213 - 6216
反应条件
1: With hydrogenchloride; sodium nitrite in water
T=0 - 5°C; Sandmeyer reaction;
2: With hydrogenchloride; copper(l) chloride in water
T=0°C; Sandmeyer reaction; Heating;
参考文献
Pokhodylo; Matiychuk; Obushak
Chemistry of Heterocyclic Compounds, 2010 , vol. 46, # 2 p. 140 - 145
反应条件
sodium tetrahydroborate in methanol
参考文献
Leblois, Danielle; Piessard, Sylvie; Baut, Guillaume Le; Kumar, Piyush; Brion, Jean-Daniel; et al.
European Journal of Medicinal Chemistry, 1987 , vol. 22, p. 229 - 238
反应条件
iodine; mercury(II) oxide in benzene
Ambient temperatureIrradiation;
参考文献
Kobayashi, Kazuhiro; Itoh, Masahito; Suginome, Hiroshi
Tetrahedron Letters, 1987 , vol. 28, # 29 p. 3369 - 3372
反应条件
1.1: KNO3; H2SO4
2.1: Fe / acetic acid; ethyl acetate; H2O / 1 h / Heating
2.2: 86 percent / NaHCO3 / 0.17 h / Heating
3.1: HNO2; HCl
3.2: KCl; CuCl
View Scheme
参考文献
Abaev, Vladimir T.; Dmitriev, Artem S.; Gutnov, Andrey V.; Podelyakin, Sergey A.; Butin, Alexander V.
Journal of Heterocyclic Chemistry, 2006 , vol. 43, # 5 p. 1195 - 1204
反应条件
1.1: Fe / acetic acid; ethyl acetate; H2O / 1 h / Heating
1.2: 86 percent / NaHCO3 / 0.17 h / Heating
2.1: HNO2; HCl
2.2: KCl; CuCl
View Scheme
参考文献
Abaev, Vladimir T.; Dmitriev, Artem S.; Gutnov, Andrey V.; Podelyakin, Sergey A.; Butin, Alexander V.
Journal of Heterocyclic Chemistry, 2006 , vol. 43, # 5 p. 1195 - 1204
反应条件
1: H2SO4 / acetic anhydride / 3 h / Heating
2: 83 percent / NaBH4 / methanol
View Scheme
参考文献
Leblois, Danielle; Piessard, Sylvie; Baut, Guillaume Le; Kumar, Piyush; Brion, Jean-Daniel; et al.
European Journal of Medicinal Chemistry, 1987 , vol. 22, p. 229 - 238
反应条件
acetic acid; zinc
17 h; Reflux;
参考文献
Nandhikonda, Premchendar; Heagy, Michael D.
Organic Letters, 2010 , vol. 12, # 21 p. 4796 - 4799
反应条件
chloromethylation reaction;
参考文献
Leblois, Danielle; Piessard, Sylvie; Baut, Guillaume Le; Kumar, Piyush; Brion, Jean-Daniel; et al.
European Journal of Medicinal Chemistry, 1987 , vol. 22, p. 229 - 238
