1.1: potassium hydroxide; water; copper; copper(II) oxide / 1 h / 140 °C / |Inert atmosphere; |Microwave irradiation 2.1: 3,4,5-trimethoxyphenylboronic acid / toluene / 1 h / |Reflux; |Dean-Stark 2.2: 46 h / 100 °C / |Molecular sieve; |Sealed tube 2.3: 2 h / |Reflux 3.1: potassium carbonate / acetone / 4 h / |Reflux 4.1: ethanol / 14 h / |Reflux 5.1: pyridine / dichloromethane / 1.5 h / 0 - 20 °C 6.1: trichlorophosphate / acetonitrile / 1 h / |Reflux; |Inert atmosphere 7.1: [[(η6-p-cymene)((1S,2S)-N-p-toluenesulfonyl-1,2-diphenylethylenediamine)]Ru]; formic acid; triethylamine / N,N-dimethyl-formamide / 20 °C 8.1: water; sodium hydroxide / ethanol / 3 h / 20 °C 9.1: thionyl chloride / dichloromethane / 1.5 h / 0 - 20 °C 10.1: sodium hydrogencarbonate / dichloromethane / 1.5 h / 20 °C View Scheme

hydrogenchloride; sodium borohydride; Calcium chloride in tetrahydrofuran; water

1.1: potassium hydroxide; water; copper; copper(II) oxide / 1 h / 140 °C / |Inert atmosphere; |Microwave irradiation 2.1: 3,4,5-trimethoxyphenylboronic acid / toluene / 1 h / |Reflux; |Dean-Stark 2.2: 46 h / 100 °C / |Molecular sieve; |Sealed tube 2.3: 2 h / |Reflux 3.1: potassium carbonate / acetone / 4 h / |Reflux 4.1: ethanol / 14 h / |Reflux 5.1: pyridine / dichloromethane / 1.5 h / 0 - 20 °C 6.1: trichlorophosphate / acetonitrile / 1 h / |Reflux; |Inert atmosphere 7.1: [[(η6-p-cymene)((1S,2S)-N-p-toluenesulfonyl-1,2-diphenylethylenediamine)]Ru]; formic acid; triethylamine / N,N-dimethyl-formamide / 20 °C 8.1: water; sodium hydroxide / ethanol / 3 h / 20 °C 9.1: thionyl chloride / dichloromethane / 1.5 h / 0 - 20 °C 10.1: sodium hydrogencarbonate / dichloromethane / 1.5 h / 20 °C View Scheme

1.1: potassium hydroxide; water; copper; copper(II) oxide / 1 h / 140 °C / |Inert atmosphere; |Microwave irradiation 2.1: 3,4,5-trimethoxyphenylboronic acid / toluene / 1 h / |Reflux; |Dean-Stark 2.2: 46 h / 100 °C / |Molecular sieve; |Sealed tube 2.3: 2 h / |Reflux 3.1: potassium carbonate / acetone / 4 h / |Reflux 4.1: ethanol / 14 h / |Reflux 5.1: pyridine / dichloromethane / 1.5 h / 0 - 20 °C 6.1: trichlorophosphate / acetonitrile / 1 h / |Reflux; |Inert atmosphere 7.1: [[(η6-p-cymene)((1S,2S)-N-p-toluenesulfonyl-1,2-diphenylethylenediamine)]Ru]; formic acid; triethylamine / N,N-dimethyl-formamide / 20 °C 8.1: water; sodium hydroxide / ethanol / 3 h / 20 °C 9.1: thionyl chloride / dichloromethane / 1.5 h / 0 - 20 °C 10.1: sodium hydrogencarbonate / dichloromethane / 1.5 h / 20 °C 11.1: hydrogenchloride / water; ethanol / 2 h / |Reflux View Scheme

sodium hydroxide in methanol 1.5 h; Ambient temperature;

water; copper; copper(II) oxide; potassium hydroxide T=140°C; 1 h; Inert atmosphereMicrowave irradiation;

sodium hydride in N,N-dimethyl-formamide T=100°C; 0.333333 h;

1: 70 percent / NBS, 48percent aq. HBr / CCl4 / Heating 2: 30 percent / NaOMe / diethyl ether / 24 h / Ambient temperature 3: 44 percent / KOH / ethanol; H2O / 6 h / Heating 4: 51 percent / urea / xylene / Heating 5: 43 percent / BH3 / tetrahydrofuran / 1 h / 100 °C View Scheme

(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate in ethylene glycol dimethyl ether T=110°C; 18 h; Heating;

1.1: potassium hydroxide; water; copper; copper(II) oxide / 1 h / 140 °C / |Inert atmosphere; |Microwave irradiation 2.1: 3,4,5-trimethoxyphenylboronic acid / toluene / 1 h / |Reflux; |Dean-Stark 2.2: 46 h / 100 °C / |Molecular sieve; |Sealed tube 2.3: 2 h / |Reflux 3.1: potassium carbonate / acetone / 4 h / |Reflux View Scheme