4,7-二氯喹啉-3-羧酸乙酯合成路线 （共 9 条）
参考文献
Farmaco, , vol. 45, # 3 p. 269 - 284
反应条件
trichlorophosphate T=120°C; 0.25 h;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 23 p. 6505 - 6510
反应条件
1: in diphenylether T=250°C; 1 h; 2: With thionyl chloride T=80°C; 1 h;
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 21 p. 6351 - 6363
反应条件
1.1: pyridine / toluene / 2 h / Heating 2.1: diphenyl ether / 1 h / 250 °C 2.2: 350 mg / thionyl chloride / 1 h / 80 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 21 p. 6351 - 6363
反应条件
1.1: pyridine / toluene / 2 h / Heating 2.1: diphenyl ether / 1 h / 250 °C 2.2: 350 mg / thionyl chloride / 1 h / 80 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 21 p. 6351 - 6363
反应条件
1: various solvent(s) / 0.5 h / 250 °C 2: POCl3 / 5 h / Heating View Scheme
参考文献
Farmaco, , vol. 53, # 8-9 p. 579 - 585
反应条件
sodium azide in N,N-dimethyl-formamide
T=20 - 25°C; 2 h;
参考文献
Ghotekar, Bhausaheb Kedarnath; Ghagare, Maruti G.; Toche, Raghunath B.; Jachak, Madhukar N.
Monatshefte fur Chemie, 2010 , vol. 141, # 2 p. 169 - 175
反应条件
sodium azide in ethanol; water
24 h; Heating;
参考文献
Savini; Massarelli; Pellerano
Farmaco, 1993 , vol. 48, # 4 p. 515 - 528
反应条件
1: With lithium hydroxide dihydrate; water in acetonitrile
T=20°C; 6 h; Cooling with ice;
2: With hydrogenchloride in water
pH=~ 8 - 9;
参考文献
AMGEN INC.; FISHER, Benjamin; JOHNSON, Michael G.; LUCAS, Brian; SHIN, Youngsook; KAIZERMAN, Amy
Patent: WO2012/61696 A1, 2012 ;
Location in patent: Page/Page column 58 ;
WO 2012/061696 A1
