1-乙基-4-(叔丁基氧基羰基)哌嗪-2-酮合成路线 (共 4 条)
反应条件
1: 1-tert-Butoxycarbonyl-3-oxopiperazine With sodium hydride in N,N-dimethyl-formamide T=0°C; 0.416667 h; 2: ethyl iodide in N,N-dimethyl-formamide T=40°C; 15 h;
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: EP1785418 A1, 2007 ;
Location in patent: Page/Page column 72 ;
反应条件
sodium hydride in N,N-dimethyl-formamide T=20°C;
参考文献
Martini, Elisabetta; Ghelardini, Carla; Dei, Silvia; Guandalini, Luca; Manetti, Dina; Melchiorre, Michele; Norcini, Monica; Scapecchi, Serena; Teodori, Elisabetta; Romanelli, Maria Novella
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 3 p. 1431 - 1443
参考文献
Cumming; Le; Babu; Carroll; Chen; Favreau; Gaspari; Guo; Hobbs; Huang; Iserloh; Kennedy; Kuvelkar; Li; Lowrie; McHugh; Ozgur; Pan; Parker; Saionz; Stamford; Strickland; Tadesse; Voigt; Wang; Wu; Zhang
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 11 p. 3236 - 3241
反应条件
trifluoroacetic acid T=20°C; 3 h;
参考文献
PRINCIPIA BIOPHARMA INC.; OWENS, Tim; VERNER, Erik
Patent: WO2014/39899 A1, 2014 ;
Location in patent: Page/Page column 89 ;