2,4-二甲基-3-吡啶甲醇合成路线 (共 6 条)
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0 - 20°C; 2 h;
参考文献
TEMPERO PHARMACEUTICALS, INC.; BALOGLU, Erkan; GHOSH, Shomir; LOBERA, Mercedes; SCHMIDT, Darby, R.
Patent: WO2013/19621 A1, 2013 ;
Location in patent: Page/Page column 40 ;
WO 2013/019621 A1
参考文献
Merck and Co., Inc.
Patent: US5726172 A1, 1998 ;
US 5726172 A
反应条件
1: 1 N aq. (NH4)2Ce(NO3)6 / acetone / 0.33 h / 0 °C 2: LiAlH4 / tetrahydrofuran / 2 h / 0 °C View Scheme
参考文献
Ueyama; Yanagisawa; Kawai; Sonegawa; Baba; Mochizuki; Kosakai; Tomiyama
Chemical and Pharmaceutical Bulletin, 1994 , vol. 42, # 9 p. 1841 - 1849
反应条件
thionyl chloride in dichloromethane 4 h; Ambient temperature;
参考文献
JAPAN TOBACCO INC.
Patent: WO2006/126695 A1, 2006 ;
Location in patent: Page/Page column 259 ;
反应条件
thionyl chloride in chloroform
参考文献
Japan Tobacco Inc.
Patent: US2007/32529 A1, 2007 ;
US 20070032529 A1
反应条件
1: diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 0 - 20 °C
2: palladium 10 on activated carbon; hydrogen / methanol / 3 h
View Scheme
参考文献
NOVARTIS AG; FLOHR, Stefanie; MARKERT, Christian; NAMOTO, Kenji; PIRARD, Bernard
Patent: WO2013/111108 A1, 2013 ;