2-乙酰氨基-6-氯-苯甲酸合成路线 （共 15 条）
反应条件
potassium permanganate; magnesium sulfate in water T=135 - 160°C; 5 h;
参考文献
Jin, Yi; Li, Hui-Yuan; Lin, Li-Ping; Tan, Jinzhi; Ding, Jian; Luo, Xiaomin; Long, Ya-Qiu
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 19 p. 5613 - 5622
反应条件
1: sodium acetate 2: potassium permanganate; magnesium sulfate; water View Scheme
参考文献
Journal of the American Chemical Society, , vol. 55, p. 2559,2563
反应条件
1: 90.2 percent / CH2Cl2 2: 65.7 percent / potassium permanganate; magnesium sulfate heptahydrate / H2O / 5 h / 135 - 160 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 13, # 19 p. 5613 - 5622
反应条件
potassium permanganate; magnesium sulfate 1) reflux, 30 min, 2) 85-90 deg C, 1.5 h; Yield given. Multistep reaction;
参考文献
Journal of Medicinal Chemistry, , vol. 32, # 10 p. 2247 - 2254
参考文献
Monatshefte fuer Chemie, , vol. 22, p. 485
反应条件
1: concentrated hydrochloric acid / Zers. des entstandenen Hydrochlorids mit Natriumdicarbonat 2: Diazotization.Einw. von CuCl und HCl auf das Diazotierungsprodukt View Scheme
参考文献
Cohn,P.
Monatshefte fuer Chemie, 1901 , vol. 22, p. 485
反应条件
1: 74 percent / diethyl ether / 0.5 h 2: HCl / methanol / 1 h / Heating View Scheme
参考文献
Schneller, Stewart W.; Ibay, Augusto C.; Christ, William J.; Bruns, Robert F.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 10 p. 2247 - 2254
反应条件
1: aqueous hydrochloric acid 2: aqueous hydrochloric acid; sodium nitrite / Diazotization.Eintragen der erhaltenen Diazoniumsalz-Loesung in eine aus Kupfer(II)-sulfat, Schwefeldioxid und wss. Ammoniak hergestellte Loesung 3: acetic acid anhydride 4: 310 °C View Scheme
参考文献
Huntress; Cliff
Journal of the American Chemical Society, 1933 , vol. 55, p. 2559,2563
反应条件
1: hydrochloric acid / 1.5 h / 80 - 90 °C 2: 67.6 percent / 2 h / 130 - 175 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 13, # 19 p. 5613 - 5622
