6-羟基-2(1H)-喹啉酮合成路线 （共 18 条）
反应条件
aluminium trichloride in chlorobenzene T=120°C; 2 h;
参考文献
Wang, Tai-Chi; Chen, Yeh-Long; Lee, Kuan-Han; Tzeng, Cherng-Chyi
Synthesis, 1997 , # 1 p. 87 - 90
反应条件
hydrogen bromide in water 48 h; Heating;
参考文献
Seyedi, Seyed Mohammad; Sadeghian, Hamid; Arghiani, Zahra
Heterocyclic Communications, 2008 , vol. 14, # 3 p. 183 - 186
反应条件
sodium hydroxide 1.5 h;
参考文献
Wang, Tai-Chi; Chen, Yeh-Long; Lee, Kuan-Han; Tzeng, Cherng-Chyi
Synthesis, 1997 , # 1 p. 87 - 90
反应条件
1: 82 percent / isobutyl chloroformiate / CHCl3; triethylamine / 12 h / Ambient temperature 2: 82 percent / aluminium chloride / chlorobenzene / 2 h / 100 - 110 °C View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 20, # 2 p. 121 - 125
反应条件
1: acetic anhydride / 18 h / 75 °C 2: 69 percent / 48percent HBr / 18 h / 80 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 29, # 10 p. 2024 - 2028
反应条件
1: 22 percent / 2 h / Heating 2: 91 percent / 1.0 N aq. NaOH / 1.5 h View Scheme
参考文献
Synthesis, , # 1 p. 87 - 90
反应条件
potassium carbonate in N,N-dimethyl-formamide T=80°C; 7 h;
参考文献
Heterocycles, , vol. 78, # 1 p. 189 - 195
反应条件
1: trichlorophosphate / tetrahydrofuran / 65 °C 2: potassium carbonate / N,N-dimethyl-formamide View Scheme
参考文献
Ramurthy, Savithri; Costales, Abran; Jansen, Johanna M.; Levine, Barry; Renhowe, Paul A.; Shafer, Cynthia M.; Subramanian, Sharadha
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 4 p. 1678 - 1681
反应条件
1: 74 percent / 1,8-diazabicyclo<5,4,0>undec-7-ene (DBU) / propan-2-ol / 4 h / Heating
2: 95 percent / 20percent HCl / 2 h / 85 - 90 °C
3: 1.) isobutyl chloroformate, 1,8-diazabicyclo<5,4,0>undec-7-ene (DBU) / 1.) CHCl3, r.t., 1 h, 2.) CHCl3, r.t., 3 h
View Scheme
参考文献
Nishi; Tabusa; Tanaka; Ueda; Shimizu; Kanbe; Kimura; Nakagawa
Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 3 p. 852 - 860
参考文献
Boehringer Ingelheim GmbH
Patent: US4329347 A1, 1982 ;
