4,4-二甲基-2-苯基-2-噁唑啉合成路线 （共 73 条）
反应条件
palladium diacetate; copper diacetate; p-benozquinone in acetonitrile
T=100°C; 41 h;
参考文献
Chen, Xiao; Li, Jiao-Jie; Hao, Xue-Shi; Goodhue, Charles E.; Yu, Jin-Quan
Journal of the American Chemical Society, 2006 , vol. 128, # 1 p. 78 - 79
反应条件
palladium diacetate
1.) acetic acid, 2.) CH2Cl2, trifluoroacetic acid, 25 deg C, 24 h; Yield given. Multistep reaction;
参考文献
Clinet, J. C.; Balavoine, G.
Journal of Organometallic Chemistry, 1991 , vol. 405, # 2 p. C29 - C31
反应条件
1: With (nBu)3MgLi in tetrahydrofuran; hexane
T=20°C; Inert atmosphere;
2: With N-fluorobenzene sulfonamide in tetrahydrofuran; hexane
T=20°C; Inert atmosphere;
参考文献
Bellamy, Estelle; Bayh, Omar; Hoarau, Christophe; Trecourt, Francois; Queguiner, Guy; Marsais, Francis
Chemical Communications, 2010 , vol. 46, # 37 p. 7043 - 7045
反应条件
1: With tert-butyl methyl ether; nitric acid in tetrahydrofuran
T=0°C;
2: With sulfuric acid in dichloromethane
T=0°C; 1 h; Further stages.;
参考文献
Zhang, Pingsheng; Cedilote, Miall; Cleary, Thomas P.; Pierce, Michael E.
Tetrahedron Letters, 2007 , vol. 48, # 49 p. 8659 - 8664
反应条件
1: 1.) sec-BuLi / 1.) THF, cyclohexane, 2.) THF, cyclohexane, RT, 6 h
2: 5percent aq. HCl / 8 h / Heating
3: 96 percent / H2, glacial acetic acid / 10percent Pd/C / 8 h / 80 °C / 2585.7 Torr
View Scheme
参考文献
Snyder, Scott E.; Aviles-Garay, Felix A.; Chakraborti, Ratna; Nichols, David E.; Watts, Val J.; Mailman, Richard B.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 13 p. 2395 - 2409
反应条件
1.1: n-BuLi / hexane; tetrahydrofuran / 3.5 h
1.2: 58 percent / cuprous bromide / hexane; tetrahydrofuran / 1.5 h / 0 °C
2.1: dimethylsulfoxide / 20 °C
3.1: 2.54 g / NaOH / H2O / 8 h / Heating
4.1: diethyl cyanophosphonate / dimethylformamide / 0.5 h / 0 °C
4.2: 39 percent / Et3N / dimethylformamide / 2 h / 0 °C
5.1: 80 percent / tetraethylammonium tosylate / dimethylformamide / 60 °C / Electrolysis
View Scheme
参考文献
Ozaki, Shigeko; Adachi, Masashi; Sekiya, Sayaka; Kamikawa, Rie
Journal of Organic Chemistry, 2003 , vol. 68, # 11 p. 4586 - 4589
反应条件
triethylamine in cyclohexane
参考文献
Johnson; Caldwell
Journal of Organic Chemistry, 1973 , vol. 38, # 26 p. 4465 - 4467
反应条件
1: Et3N / cyclohexane
2: 3 h / Heating
View Scheme
参考文献
Johnson; Caldwell
Journal of Organic Chemistry, 1973 , vol. 38, # 26 p. 4465 - 4467
反应条件
palladium diacetate in acetonitrile
0.166667 h; HeatingInert atmosphere;
参考文献
Yu, Wing-Yiu; Sit, Wing Nga; Zhou, Zhongyuan; Chan, Albert S.-C.
Organic Letters, 2009 , vol. 11, # 15 p. 3174 - 3177
反应条件
palladium diacetate
1.) acetic acid, 2.) CH2Cl2, trifluoroacetic acid, 25 deg C, 24 h; Yield given. Multistep reaction;
参考文献
Clinet, J. C.; Balavoine, G.
Journal of Organometallic Chemistry, 1991 , vol. 405, # 2 p. C29 - C31
