4,4-二甲基-2-苯基-2-噁唑啉合成路线 （共 73 条）
反应条件
diisobutylaluminium hydride in diethyl ether 2.5 h; Ambient temperatureLi/NH3 as reagent, reaction time of 0.5 h; MechanismProduct distribution;
参考文献
Ryan, Christopher M.; Kariv-Miller, Essie
Tetrahedron, 1988 , vol. 44, # 22 p. 6807 - 6810
反应条件
1.1: n-BuLi / hexane; tetrahydrofuran / 3.5 h 1.2: 58 percent / cuprous bromide / hexane; tetrahydrofuran / 1.5 h / 0 °C 2.1: dimethylsulfoxide / 20 °C 3.1: 2.54 g / NaOH / H2O / 8 h / Heating View Scheme
参考文献
Ozaki, Shigeko; Adachi, Masashi; Sekiya, Sayaka; Kamikawa, Rie
Journal of Organic Chemistry, 2003 , vol. 68, # 11 p. 4586 - 4589
反应条件
sodium hydroxide; n-butyllithium; copper(I) bromide; methyl iodide Yield given. Multistep reaction;
参考文献
Grunewald; Dahanukar
Journal of Heterocyclic Chemistry, 1994 , vol. 31, # 6 p. 1609 - 1617
反应条件
hydrogenchloride; n-butyllithium; magnesium bromide Yield given. Multistep reaction;
参考文献
Boulet, Camille Andre; Poulton, Gerald Arthur
Heterocycles, 1989 , vol. 28, # 1 p. 405 - 410
反应条件
1: 1.) BuLi / 1.) THF, -45 deg C, 2.) -100 deg C 2: 5percent aq. HCl / Heating; overnight View Scheme
参考文献
Edgar; Bradsher
Journal of Organic Chemistry, 1982 , vol. 47, # 8 p. 1585 - 1587
反应条件
hydrogenchloride in diethyl ether 0.166667 h;
参考文献
Singh, Harjit; Sarin, Rakesh
Tetrahedron, 1986 , vol. 42, # 5 p. 1449 - 1460
反应条件
1: With (nBu)3MgLi in tetrahydrofuran; hexane T=20°C; Inert atmosphere; 2: With oxygen in tetrahydrofuran; hexane T=20°C; 0.166667 h;
参考文献
Bellamy, Estelle; Bayh, Omar; Hoarau, Christophe; Trecourt, Francois; Queguiner, Guy; Marsais, Francis
Chemical Communications, 2010 , vol. 46, # 37 p. 7043 - 7045
反应条件
1: 1.) BuLi / 1.) THF, -45 deg C, 2.) -100 deg C 2: 5percent aq. HCl / Heating; overnight View Scheme
参考文献
Edgar; Bradsher
Journal of Organic Chemistry, 1982 , vol. 47, # 8 p. 1585 - 1587
反应条件
1.1: n-butyllithium / tetrahydrofuran
2.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 4 h / 0 - 20 °C
2.2: 2.5 h / 60 °C
3.1: hydrogenchloride / 30 h / Reflux
View Scheme
参考文献
Clark, Alia H.; McCorvy, John D.; Watts, Val J.; Nichols, David E.
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 18 p. 5420 - 5431
反应条件
1: HCl gas / diethyl ether / 0.17 h
2: 10 percent / Et3N / acetonitrile / RT, 2 h, then reflux, 10 h
View Scheme
参考文献
Singh, Harjit; Sarin, Rakesh
Tetrahedron, 1986 , vol. 42, # 5 p. 1449 - 1460
