1-甲基-3,5-二苯基-吡唑合成路线 （共 73 条）
反应条件
potassium hydrogensulfate in methanol
T=50°C; 4 h; Title compound not separated from byproducts;
参考文献
Zielinska-Blajet, Mariola; Kowalczyk, Rafal; Skarzewski, Jacek
Tetrahedron, 2005 , vol. 61, # 22 p. 5235 - 5240
反应条件
triethylamine
T=100°C; 3 h;
参考文献
Fliege, Werner; Grashey, Rudolf; Huisgen, Rolf
Chemische Berichte, 1984 , vol. 117, # 3 p. 1194 - 1214
反应条件
titanium tetrachloride in 1,2-dichloro-benzene
T=115 - 125°C; 0.5 h;
参考文献
Ito, Suketaka; Tanaka, Yumo; Kakehi, Akikazu; Fukuyama, Toshihiko; Osawa, Nobuo; Sayo, Noboru
Bulletin of the Chemical Society of Japan, 1983 , vol. 56, # 2 p. 545 - 548
反应条件
in neat (no solvent)
T=0°C; 7 h;
参考文献
Harris, D. J.; Kan, G. Y.-P.; Tschamber, T.; Snieckus, V.
Canadian Journal of Chemistry, 1980 , vol. 58, p. 494 - 500
反应条件
chloranil in xylene
6 h; Heating;
参考文献
Fliege, Werner; Grashey, Rudolf; Huisgen, Rolf
Chemische Berichte, 1984 , vol. 117, # 3 p. 1194 - 1214
反应条件
potassium hydrogensulfate in methanol
T=50°C; 4 h; Title compound not separated from byproducts;
参考文献
Zielinska-Blajet, Mariola; Kowalczyk, Rafal; Skarzewski, Jacek
Tetrahedron, 2005 , vol. 61, # 22 p. 5235 - 5240
反应条件
1.1: trifluorormethanesulfonic acid / 1,2-dichloro-ethane / 0.17 h / 20 °C / |Inert atmosphere
1.2: 12 h / |Inert atmosphere; |Reflux
2.1: sodium hydride / tetrahydrofuran / 0.5 h / 20 °C
2.2: 16 h / 20 °C
View Scheme
参考文献
Liu, Ping; Xu, Qian-Qian; Dong, Chao; Lei, Xinsheng; Lin, Guo-Qiang
Synlett, 2012 , vol. 23, # 14 p. 2087 - 2092
反应条件
1.1: methanol / 0.5 h / 20 - 60 °C
2.1: trifluorormethanesulfonic acid / 1,2-dichloro-ethane / 0.17 h / 20 °C / |Inert atmosphere
2.2: 12 h / |Inert atmosphere; |Reflux
3.1: sodium hydride / tetrahydrofuran / 0.5 h / 20 °C
3.2: 16 h / 20 °C
View Scheme
参考文献
Liu, Ping; Xu, Qian-Qian; Dong, Chao; Lei, Xinsheng; Lin, Guo-Qiang
Synlett, 2012 , vol. 23, # 14 p. 2087 - 2092
反应条件
potassium phosphate; tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran
Suzuki-Miyaura coupling; 18 h; RefluxInert atmosphere;
参考文献
Beltran-Rodil, Sandra; Edwards, Michael G.; Pugh, David S.; Reid, Mark; Taylor, Richard J.K.
Synlett, 2010 , # 4 art. no. D27509ST, p. 602 - 606
反应条件
1: With anhydrous iron chloride in chlorobenzene
T=60°C; 1 h;
2: With caesium carbonate in chlorobenzene
T=100°C; 3 h; regioselective reaction;
参考文献
Hao, Lu; Hong, Jun-Jie; Zhu, Jun; Zhan, Zhuang-Ping
Chemistry - A European Journal, 2013 , vol. 19, # 18 p. 5715 - 5720
