7-氨基-1,8-萘啶-2(8h)-酮合成路线 （共 12 条）
反应条件
sodium hydroxide in water T=0°C; pH=> 10; 0.5 h;
参考文献
Pfizer Inc.
Patent: US2008/167319 A1, 2008 ;
Location in patent: Page/Page column 7 ;
反应条件
1: With sulfuric acid T=110°C; Inert atmosphereCooling with ice; 2: With ammonium hydroxide in water pH=8; Cooling with ice;
参考文献
Anderson, Cyrus A.; Taylor, Phillip G.; Zeller, Mary A.; Zimmerman, Steven C.
Journal of Organic Chemistry, 2010 , vol. 75, # 14 p. 4848 - 4851
参考文献
Journal of the American Chemical Society, , vol. 68, p. 1317
Gazzetta Chimica Italiana, , vol. 95, p. 1492,1500
反应条件
sulfuric acid; sodium nitrite
参考文献
Newkome, George R.; Garbis, Sam J.; Majestic, Veronica K.; Fronczek, Frank R.; Chiari, Giacomo
Journal of Organic Chemistry, 1981 , vol. 46, # 5 p. 833 - 839
反应条件
1: 85 percent / 2.5 h / Heating 2: 60 percent / POCl3 / 1.5 h / 90 - 95 °C 3: 74 percent / NH3 / ethanol / 24 h / 180 °C View Scheme
参考文献
Dey, Swapan; Sain, Dibyendu; Goswami, Shyamaprosad
RSC Advances, 2014 , vol. 4, # 1 p. 428 - 433
反应条件
pyridine hydrogenfluoride; sodium nitrite T=0°C; 0.5 h;
参考文献
Pfizer Inc.
Patent: US2008/167319 A1, 2008 ;
Location in patent: Page/Page column 7 ;
反应条件
1: 76 percent / 1.) conc. sulfuric acid, sodium nitrite; 2.) Sodium carbonate / 0.25 h / 0 °C 2: 73.8 percent / phosphorus pentachloride, phosphorus trichloride oxide / 3 h / Heating View Scheme
参考文献
Newkome, George R.; Garbis, Sam J.; Majestic, Veronica K.; Fronczek, Frank R.; Chiari, Giacomo
Journal of Organic Chemistry, 1981 , vol. 46, # 5 p. 833 - 839
反应条件
trichlorophosphate 4 h; Heating;
参考文献
Goswami, Shyamaprosad; Mukherjee, Reshmi; Mukherjee, Rakhi; Jana, Subrata; Maity, Annada C.; Adak, Avijit Kumar
Molecules, 2005 , vol. 10, # 8 p. 929 - 936
反应条件
N-iodo-succinimide in N,N-dimethyl-formamide
T=80°C; 24 h;
参考文献
Hikishima, Sadao; Minakawa, Noriaki; Kuramoto, Kazuyuki; Fujisawa, Yuki; Ogawa, Maki; Matsuda, Akira
Angewandte Chemie - International Edition, 2005 , vol. 44, # 4 p. 596 - 598
反应条件
trichlorophosphate in N-methyl-acetamide; diphenylether; acetic acid
参考文献
Rhone-Poulenc Industries
Patent: US4220646 A1, 1980 ;
