7-羟基-6-甲氧基-3-((特戊酰氧基)甲基)-3,4-二氢喹唑啉-4-酮合成路线

193002-24-37-苄氧基-6-甲氧基-3-((特戊酰氧基)甲基)-3,4-二氢喹唑啉-4-酮→193002-25-47-羟基-6-甲氧基-3-((特戊酰氧基)甲基)-3,4-二氢喹唑啉-4-酮

参考文献

Zeneca Limited
Patent: US6265411 B1, 2001 ;

18997-19-8特戊酸氯甲酯→193002-25-47-羟基-6-甲氧基-3-((特戊酰氧基)甲基)-3,4-二氢喹唑啉-4-酮

参考文献

Hennequin, Laurent F.; Thomas, Andrew P.; Johnstone, Craig; Stokes, Elaine S. E.; Ple, Patrick A.; Lohmann, Jean-Jacques M.; Ogilvie, Donald J.; Dukes, Mike; Wedge, Steve R.; Curwen, Jon O.; Kendrew, Jane; Lambert-Van Der Brempt, Christine
Journal of Medicinal Chemistry, 1999 , vol. 42, # 26 p. 5369 - 5389

60547-98-02-氨基-4-苄氧基-5-甲氧基苯甲酰胺→193002-25-47-羟基-6-甲氧基-3-((特戊酰氧基)甲基)-3,4-二氢喹唑啉-4-酮

参考文献

Hennequin, Laurent F.; Thomas, Andrew P.; Johnstone, Craig; Stokes, Elaine S. E.; Ple, Patrick A.; Lohmann, Jean-Jacques M.; Ogilvie, Donald J.; Dukes, Mike; Wedge, Steve R.; Curwen, Jon O.; Kendrew, Jane; Lambert-Van Der Brempt, Christine
Journal of Medicinal Chemistry, 1999 , vol. 42, # 26 p. 5369 - 5389

179688-01-86-甲氧基-7-苄氧基喹唑啉-4-酮→193002-25-47-羟基-6-甲氧基-3-((特戊酰氧基)甲基)-3,4-二氢喹唑啉-4-酮

参考文献

Hennequin, Laurent F.; Thomas, Andrew P.; Johnstone, Craig; Stokes, Elaine S. E.; Ple, Patrick A.; Lohmann, Jean-Jacques M.; Ogilvie, Donald J.; Dukes, Mike; Wedge, Steve R.; Curwen, Jon O.; Kendrew, Jane; Lambert-Van Der Brempt, Christine
Journal of Medicinal Chemistry, 1999 , vol. 42, # 26 p. 5369 - 5389

193002-25-47-羟基-6-甲氧基-3-((特戊酰氧基)甲基)-3,4-二氢喹唑啉-4-酮→264208-72-24-氯-6-甲氧基-7-[(1-甲基-4-哌啶基)甲氧基]-喹唑烷

参考文献

Hennequin, Laurent F.; Stokes, Elaine S. E.; Thomas, Andrew P.; Johnstone, Craig; Ple, Patrick A.; Ogilvie, Donald J.; Dukes, Michael; Wedge, Stephen R.; Kendrew, Jane; Curwen, Jon O.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 6 p. 1300 - 1312

123855-51-6N-Boc-4-哌啶甲醇+193002-25-47-羟基-6-甲氧基-3-((特戊酰氧基)甲基)-3,4-二氢喹唑啉-4-酮→264208-86-8

参考文献

AstraZeneca AB
Patent: EP1244647 B1, 2006 ;
Location in patent: Page/Page column 22-23 ;
EP 1244647 B1

193002-25-47-羟基-6-甲氧基-3-((特戊酰氧基)甲基)-3,4-二氢喹唑啉-4-酮+166815-96-9N-Boc-4-(4-甲苯磺酰氧基甲基)哌啶→264208-86-8

参考文献

AstraZeneca AB
Patent: EP1119567 B1, 2005 ;
Location in patent: Page/Page column 45 ;

193002-25-47-羟基-6-甲氧基-3-((特戊酰氧基)甲基)-3,4-二氢喹唑啉-4-酮→264208-69-76-甲氧基-7-((1-甲基哌啶-4-基)甲氧基)喹唑啉-4(3h)-酮

参考文献

Hennequin, Laurent F.; Stokes, Elaine S. E.; Thomas, Andrew P.; Johnstone, Craig; Ple, Patrick A.; Ogilvie, Donald J.; Dukes, Michael; Wedge, Stephen R.; Kendrew, Jane; Curwen, Jon O.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 6 p. 1300 - 1312

193002-25-47-羟基-6-甲氧基-3-((特戊酰氧基)甲基)-3,4-二氢喹唑啉-4-酮→288383-71-14-氯-6-甲氧基-7-(3-(哌啶-1-基)丙氧基)喹唑啉

参考文献

Ple, Patrick A.; Green, Tim P.; Hennequin, Laurent F.; Curwen, Jon; Fennell, Michael; Allen, Jack; Lambert-Van Der Brempt, Christine; Costello, Gerard
Journal of Medicinal Chemistry, 2004 , vol. 47, # 4 p. 871 - 887