4-氯-3,5-二硝基苯甲腈合成路线 （共 12 条）
反应条件
tetrabutylammomium bromide; copper (II) acetate monohydrate; potassium iodide in water T=180°C; 22 h;
参考文献
Ren, Yunlai; Zhao, Shuang; Tian, Xinzhe; Liu, Zhifei; Wang, Jianji; Yin, Weiping
Letters in Organic Chemistry, 2009 , vol. 6, # 7 p. 564 - 567
反应条件
tetrabutylammomium bromide; copper (II) acetate monohydrate in water T=180°C; 22 h;
参考文献
Ren, Yunlai; Zhao, Shuang; Tian, Xinzhe; Liu, Zhifei; Wang, Jianji; Yin, Weiping
Letters in Organic Chemistry, 2009 , vol. 6, # 7 p. 564 - 567
反应条件
(i) PCl5, (ii) (heating); Multistep reaction;
参考文献
Journal of the Chemical Society, , p. 1132 - 1135
反应条件
1: SnCl2, aq. HCl 2: Et3N / dimethylformamide 3: aq. NaOH / CH2Cl2 View Scheme
参考文献
Wright,J.B. et al.
Journal of Medicinal Chemistry, 1978 , vol. 21, p. 930 - 935
反应条件
sodium hydrogencarbonate in ethanol 2 h; Reflux;
参考文献
Paun, Anca; Zarafu, Irina; Caproiu, Miron T.; Ionita, Petre
Arkivoc, 2013 , vol. 2013, # 4 p. 144 - 151
参考文献
Pollitt,R.J.; Saunders,B.C.
Journal of the Chemical Society, 1964 , p. 1132 - 1135
反应条件
Ullmann condensation; Heating;
参考文献
Bhattacharya, Gautam; Salem, Manar M; Werbovetz, Karl A
Bioorganic and medicinal chemistry letters, 2002 , vol. 12, # 17 p. 2395 - 2398
反应条件
1: Heating 2: concd H2SO4 / 50 °C View Scheme
参考文献
Bhattacharya, Gautam; Salem, Manar M; Werbovetz, Karl A
Bioorganic and medicinal chemistry letters, 2002 , vol. 12, # 17 p. 2395 - 2398
参考文献
Novartis Consumer Health S.A.
Patent: US5877340 A1, 1999 ;
反应条件
sodium hydroxide in hydrogenchloride
参考文献
The Upjohn Company
Patent: US3993679 A1, 1976 ;
