3-(4-甲氧基苯基)丙酸合成路线 （共 94 条）
反应条件
PPA; Polyphosphoric acid (PPA) T=70 - 80°C; 0.5 h; Yields of byproduct given;
参考文献
Zhang, Juan; Hertzler, Russell L.; Holt, Elizabeth M.; Vickstrom, Thayne; Eisenbraun, Edmund J.
Journal of Organic Chemistry, 1993 , vol. 58, # 3 p. 556 - 559
反应条件
1: 1.) SOCl2, 2.) AlCl3 / 2.) CH2Cl2 2: NaBH4 / methanol / 0.5 h / Ambient temperature 3: toluene-p-sulphonic acid / benzene / Heating View Scheme
参考文献
Phialas, Memnon; Sammes, Peter G.; Kennewell, Peter D.; Westwood, Robert
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 4 p. 687 - 695
反应条件
lithium aluminium tetrahydride
参考文献
Fort; Roberts
Journal of the American Chemical Society, 1956 , vol. 78, p. 584,589
反应条件
triethylamine in tetrahydrofuran; hexane; L-phenylalanine
反应条件
thionyl chloride in toluene Heating;
参考文献
Drag, Marcin; Grembecka, Jolanta; Pawelczak, Malgorzata; Kafarski, Pawel
European Journal of Medicinal Chemistry, 2005 , vol. 40, # 8 p. 764 - 771
反应条件
PPA; Polyphosphoric acid (PPA) T=70 - 80°C; 0.5 h; Yields of byproduct given;
参考文献
Zhang, Juan; Hertzler, Russell L.; Holt, Elizabeth M.; Vickstrom, Thayne; Eisenbraun, Edmund J.
Journal of Organic Chemistry, 1993 , vol. 58, # 3 p. 556 - 559
反应条件
Novozym 435; acylase I from Aspergillus melleus; amano lipase AK from pseudomonas fluorescens; lipase from wheat germ; papaine in toluene T=40°C; 48 h; Enzymatic reaction; Mechanism;
参考文献
Zysk, Malgorzata; Zadlo, Anna; Brodzka, Anna; Wisniewska, Catalina; Ostaszewski, Ryszard
Journal of Molecular Catalysis B: Enzymatic, 2014 , vol. 102, p. 225 - 229
反应条件
thionyl chloride; sodium chloride; sodium hydrogencarbonate in methanol; ethyl acetate
参考文献
Chugai Seiyaku Kabushiki Kaisha
Patent: US4965405 A1, 1990 ;
反应条件
1: 3-(4-methoxyphenyl)-propionic acid With 1H-imidazole; iodine; tris-(o-tolyl)phosphine in dichloromethane T=20°C; Garegg-Samuelsson type reaction; 0.0833333 h; 2: methanol in dichloromethane T=20°C; Garegg-Samuelsson type reaction;
参考文献
Morcillo, Sara P.; Alvarez De Cienfuegos, Luis; Mota, Antonio J.; Justicia, Jose; Robles, Rafael
Journal of Organic Chemistry, 2011 , vol. 76, # 7 p. 2277 - 2281
反应条件
methanol Esterification;
参考文献
DeLong, Mitchell A.; Amburgey, Jack; Taylor, Cynthia; Wos, John A.; Soper, David L.; Wang, Yili; Hicks, Renee
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 14 p. 1519 - 1522
